Biomaterial Database

Aminophylline pharmacokinetics and cardiorespiratory effects during halothane anesthesia in experimental animals. 1980

J A Stirt, and J M Berger, and S M Ricker, and S F Sullivan

The pharmacokinetics and cardiorespiratory effects of aminophylline during halothane anesthesia are not well established and are the subject of this study. Eleven dogs were anesthetized with 1% halothane in air and given 10 mg/kg of intravenous aminophylline (theophylline ethylenediamine) over 5 minutes. Serum theophylline levels were measured over the next 60 minutes and were found to be in the therapeutic range (10-20 mg/L). Theophylline levels decayed according to a two-component exponential function. The half-time for the fast component was 4.5 minutes, while the slow component half-time was 134.5 minutes. Heart rate increased significantly (p less than 0.05) within 2 minutes following aminophylline, and remained significantly elevated for 60 minutes. Pulmonary capillary wedge pressure and systemic vascular resistance decreased 2 minutes after aminophylline, as did the arterial-mixed venous oxygen content difference. Cardiac index increased 2 minutes following aminophylline. All these changes were transient, and values returned to near control values within 10 minutes after aminophylline. Arterial oxygenation, venous admixture, and physiologic dead space were not significantly (p less than 0.05) altered by aminophylline. No cardiac arrhythmias occurred. Other than a sustained 12% increase in heart rate, and transient hemodynamic changes immediately following its administration, aminophylline in therapeutic doses did not have adverse effects on cardiorespiratory function during prolonged 1% halothane anesthesia in normoxic, eucapnic dogs.

UI	MeSH Term	Description	Entries
D012119	Respiration	The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (	Breathing
D001784	Blood Gas Analysis	Measurement of oxygen and carbon dioxide in the blood.	Analysis, Blood Gas,Analyses, Blood Gas,Blood Gas Analyses,Gas Analyses, Blood,Gas Analysis, Blood
D001794	Blood Pressure	PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.	Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D005263	Femoral Artery	The main artery of the thigh, a continuation of the external iliac artery.	Common Femoral Artery,Arteries, Common Femoral,Arteries, Femoral,Artery, Common Femoral,Artery, Femoral,Common Femoral Arteries,Femoral Arteries,Femoral Arteries, Common,Femoral Artery, Common
D006221	Halothane	A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)	1,1,1-Trifluoro-2-Chloro-2-Bromoethane,Fluothane,Ftorotan,Narcotan
D006339	Heart Rate	The number of times the HEART VENTRICLES contract per unit of time, usually per minute.	Cardiac Rate,Chronotropism, Cardiac,Heart Rate Control,Heartbeat,Pulse Rate,Cardiac Chronotropy,Cardiac Chronotropism,Cardiac Rates,Chronotropy, Cardiac,Control, Heart Rate,Heart Rates,Heartbeats,Pulse Rates,Rate Control, Heart,Rate, Cardiac,Rate, Heart,Rate, Pulse
D006439	Hemodynamics	The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.	Hemodynamic
D000628	Aminophylline	A drug combination that contains THEOPHYLLINE and ethylenediamine. It is more soluble in water than theophylline but has similar pharmacologic actions. It's most common use is in bronchial asthma, but it has been investigated for several other applications.	Afonilum,Aminodur,Aminophyllin,Aminophylline DF,Cardophyllin,Carine,Clonofilin,Corophyllin,Diaphyllin,Drafilyn,Duraphyllin,Eufilina,Eufilina Venosa,Euphyllin,Euphyllin Retard,Euphylline,Godafilin,Mini-Lix,Mundiphyllin,Mundiphyllin Retard,Novophyllin,Phyllocontin,Phyllotemp,Somophyllin,Tari-Dog,Theophyllamin Jenapharm,Theophyllamine,Theophyllin EDA-ratiopharm,Theophylline Ethylenediamine,Truphylline,Ethylenediamine, Theophylline,Theophyllin EDA ratiopharm,Theophyllin EDAratiopharm
D000769	Anesthesia, Inhalation	Anesthesia caused by the breathing of anesthetic gases or vapors or by insufflating anesthetic gases or vapors into the respiratory tract.	Insufflation Anesthesia,Anesthesia, Insufflation,Inhalation Anesthesia