Biomaterial Database

Metabolic fate of [14C]dieldrin in Schistocerca gregaria with particular reference to the nervous system. 1980

G J Singh, and R A Thornhill

1. In the metabolism of [14C]dieldrin in Schistocerca gregaria, four metabolites of dieldrin were detected. Three of these have been identified as cis-aldrindiol, trans-aldrindiol and seco-aldrin dicarboxylic acid. 2. Apart from the formation of cis and trans-aldrindiol, another metabolite, M1, was detected in the nervous system. 3. The uptake of the dose of dieldrin was maximal in nerve cords followed by thoracic muscles and gut. Degradation of dieldrin was, however, not detected in thoracic muscles.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009420	Nervous System	The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses. (Stedman, 26th ed)	Nervous Systems,System, Nervous,Systems, Nervous
D004026	Dieldrin	An organochlorine insecticide whose use has been cancelled or suspended in the United States. It has been used to control locusts, tropical disease vectors, in termite control by direct soil injection, and non-food seed and plant treatment. (From HSDB)	Alvit-55,Alvit 55,Alvit55
D004149	Dioxoles
D005243	Feces	Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
D006110	Grasshoppers	Plant-eating orthopterans having hindlegs adapted for jumping. There are two main families: Acrididae and Romaleidae. Some of the more common genera are: Melanoplus, the most common grasshopper; Conocephalus, the eastern meadow grasshopper; and Pterophylla, the true katydid.	Acrididae,Locusts,Romaleidae,Grasshopper,Locust
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001711	Biotransformation	The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor
D014018	Tissue Distribution	Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.	Distribution, Tissue,Distributions, Tissue,Tissue Distributions