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The antiemetic effect of levomepromazine (Neurocil) was tested in 76 patients treated for metastasizing malignancies with cis-dichlorodiammineplatinum (II) (Platinex). In all patients conventional antiemetics had been ineffective against gastrointestinal side effects of platinum. Using levomepromazine vomiting and nausea could be successfully prevented in 47 out of 63 patients on conventional cis-platinum doses (20 mg/m2 for 5 consecutive days) and in 5 out of 13 patients on high single day dosages (100 mg/m2). In most other patients clear-cut subjective improvement occurred. The antiemetic effect of levomepromazine against cis-platinum, which ranks among the most widely used cytostatics and causes gastrointestinal symptoms, is of importance in medico-oncological practice as it causes relief for the patients.
M Higi, and
N Niederle, and
C G Schmidt, and
S Seeber
March 1979,
Toxicological European research. Recherche europeenne en toxicologie,
M Higi, and
N Niederle, and
C G Schmidt, and
S Seeber
October 1979,
La Nouvelle presse medicale,
M Higi, and
N Niederle, and
C G Schmidt, and
S Seeber
January 1979,
Therapie,
M Higi, and
N Niederle, and
C G Schmidt, and
S Seeber
June 1982,
La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris,
M Higi, and
N Niederle, and
C G Schmidt, and
S Seeber
February 1982,
La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris,
M Higi, and
N Niederle, and
C G Schmidt, and
S Seeber
May 1978,
Der Anaesthesist,
M Higi, and
N Niederle, and
C G Schmidt, and
S Seeber
April 1968,
Sovetskaia meditsina,
M Higi, and
N Niederle, and
C G Schmidt, and
S Seeber
December 1960,
Nordisk medicin,
M Higi, and
N Niederle, and
C G Schmidt, and
S Seeber
February 1981,
Zhonghua wai ke za zhi [Chinese journal of surgery],
M Higi, and
N Niederle, and
C G Schmidt, and
S Seeber
June 1979,
Monatsschrift fur Kinderheilkunde,
