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Mutagenesis data collected in the mammalian cell CHO/HGPRT assay were analyzed to study the distribution of the experimental errors associated with the test. The data neither followed the widely assumed Poisson distribution nor satisfied the usual statistical assumptions of normality and homogeneous variance of experimental errors. We transformed the data by using the power formula Y = (X + A) gamma where X is the observed mutation frequency, Y is the transformed frequency, and A and gamma are constants determined by the procedure of Box and Cox. Setting A = 1 and gamma = 0.15 we produced transformed values for which the assumptions of homogeneous variance and normal distribution were satisfied. This transformation enables one to properly use Student's t-test and dose-response analysis of variance to analyze CHO/HGPRT results. The experimental design for CHO/HGPRT mutagenesis assays is also discussed.
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May 1984,
Mutation research,
R D Snee, and
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November 1983,
Mutation research,
R D Snee, and
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July 1975,
Somatic cell genetics,
R D Snee, and
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March 1977,
Somatic cell genetics,
R D Snee, and
J D Irr
October 1987,
Mutation research,
R D Snee, and
J D Irr
January 1984,
Cancer letters,
R D Snee, and
J D Irr
October 1977,
Mutation research,
R D Snee, and
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October 1977,
Mutation research,
R D Snee, and
J D Irr
May 1975,
Mutation research,
R D Snee, and
J D Irr
July 1976,
Clinica chimica acta; international journal of clinical chemistry,
