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The hemodynamic effect of prostaglandin E1 (PGE1) on acute respiratory failure is investigated. Eight adult mongrel dogs were subjected to oleic acid-induced acute respiratory failure. Four dogs received PGE1 intravenously one hour after oleic acid injection, and four received an equal volume of saline. Cardiac output, arterial PO2 and alveolar-arterial oxygen difference decreased significantly in the saline-treated animals, and systemic vascular resistance increased. These parameters were maintained in the PGE1 group, and stroke volume and arterial-venous oxygen difference were improved. Pulmonary vascular resistance increased in both groups. This beneficial effect of PGE1 in acute respiratory failure may be related to maintenance of hemodynamics and pulmonary gas exchange and to improved tissue oxygenation.
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