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Techniques are described for isolating, cryopreserving, and culturing human mammary epithelial cells of both normal and malignant origin. The cells can be grown either in mass culture or as a clonal assay suitable for quantitating drug sensitivity. With this clonal assay plating efficiencies of 6%-41% were routinely obtained. We examined the response to adriamycin of five different primary carcinoma cultures from patients without prior drug therapy. We were able to detect heterogeneity in response to adriamycin among the breast carcinoma cultures as well as heterogeneity among subpopulations within a single carcinoma. The differences in adriamycin sensitivity were unrelated to growth rates in culture.
H S Smith, and
A J Hackett, and
S Lan, and
M R Stampfer
February 2024,
Archives of gynecology and obstetrics,
H S Smith, and
A J Hackett, and
S Lan, and
M R Stampfer
February 1982,
Gan,
H S Smith, and
A J Hackett, and
S Lan, and
M R Stampfer
December 1991,
Tumori,
H S Smith, and
A J Hackett, and
S Lan, and
M R Stampfer
February 2008,
Investigative ophthalmology & visual science,
H S Smith, and
A J Hackett, and
S Lan, and
M R Stampfer
December 1990,
In vitro cellular & developmental biology : journal of the Tissue Culture Association,
H S Smith, and
A J Hackett, and
S Lan, and
M R Stampfer
February 1975,
The American journal of anatomy,
H S Smith, and
A J Hackett, and
S Lan, and
M R Stampfer
July 2022,
Human cell,
H S Smith, and
A J Hackett, and
S Lan, and
M R Stampfer
November 1989,
International journal of radiation biology,
H S Smith, and
A J Hackett, and
S Lan, and
M R Stampfer
December 2013,
The Laryngoscope,
H S Smith, and
A J Hackett, and
S Lan, and
M R Stampfer
January 1981,
The British journal of dermatology,
