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A 53-year-old patient with metastatic testicular choriocarcinoma died of renal failure after treatment with cis-platinum and antibiotics. Serum creatinine was first noted to be elevated on day 8 of cis-dichlorodiammineplatinum (DDP) therapy. However, a sharp rise in its level occurred soon after the start of antibiotic therapy with cephalothin, gentamicin and carbenicillin. Renal failure was progressive in nature and persisted until death occurred on day 24 of therapy and after 8 days of antibiotic treatment. The most likely explanation for the progressive worsening of renal function in this patient was renal injury incurred by DDP and antibiotics. The combination of cephalothin-gentamicin should be discouraged in the treatment of patients receiving platinum.
P A Salem, and
K W Jabboury, and
M F Khalil
May 1978,
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P A Salem, and
K W Jabboury, and
M F Khalil
January 1979,
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P A Salem, and
K W Jabboury, and
M F Khalil
April 1979,
Cancer treatment reports,
P A Salem, and
K W Jabboury, and
M F Khalil
January 1977,
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P A Salem, and
K W Jabboury, and
M F Khalil
October 1976,
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P A Salem, and
K W Jabboury, and
M F Khalil
December 1975,
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P A Salem, and
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M F Khalil
June 1975,
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P A Salem, and
K W Jabboury, and
M F Khalil
January 1987,
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P A Salem, and
K W Jabboury, and
M F Khalil
October 1972,
Die Medizinische Welt,
P A Salem, and
K W Jabboury, and
M F Khalil
October 1978,
Cancer treatment reports,
