Complete reversal of chronic ethanol polydipsia by schedule withdrawal. 1982

M Tang, and C Brown, and J L Falk

Rats exposed to daily 3-hr intermittent food delivery sessions (binging) chronically ingested excessive amounts of either H2O or 5% EtOH (mean 7.1 g/kg/3-hr). Withdrawing the intermittency of the feeding schedule once every 10 days (single-ration probe session) resulted in reduction of fluid intakes (both H2O and EtOH) to the level of animals always given daily single-ration sessions. This complete dependence of elevated fluid intake levels on the intermittent feeding schedule was unaffected by either the number of probes previously administered (0 to 11) or the duration the feeding schedule was maintained before introduction of the first probe session (29 or 109 days). The results of the probe sessions demonstrated that a history of ethanol overindulgence was not a sufficient condition for the maintenance of overdrinking. Continued overindulgence required the continued presence of the original inducing conditions. Ethanol-polydipsic animals exposed to periodic probe sessions also developed a slow rise in binge session intake. No such increase was observed in the water-polydipsic animals.

UI MeSH Term Description Entries
D008297 Male Males
D004435 Eating The consumption of edible substances. Dietary Intake,Feed Intake,Food Intake,Macronutrient Intake,Micronutrient Intake,Nutrient Intake,Nutritional Intake,Ingestion,Dietary Intakes,Feed Intakes,Intake, Dietary,Intake, Feed,Intake, Food,Intake, Macronutrient,Intake, Micronutrient,Intake, Nutrient,Intake, Nutritional,Macronutrient Intakes,Micronutrient Intakes,Nutrient Intakes,Nutritional Intakes
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000431 Ethanol A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES. Alcohol, Ethyl,Absolute Alcohol,Grain Alcohol,Alcohol, Absolute,Alcohol, Grain,Ethyl Alcohol
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013375 Substance Withdrawal Syndrome Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug. Drug Withdrawal Symptoms,Withdrawal Symptoms,Drug Withdrawal Symptom,Substance Withdrawal Syndromes,Symptom, Drug Withdrawal,Symptom, Withdrawal,Symptoms, Drug Withdrawal,Symptoms, Withdrawal,Syndrome, Substance Withdrawal,Syndromes, Substance Withdrawal,Withdrawal Symptom,Withdrawal Symptom, Drug,Withdrawal Symptoms, Drug,Withdrawal Syndrome, Substance,Withdrawal Syndromes, Substance
D013894 Thirst A drive stemming from a physiological need for WATER. Thirsts
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

M Tang, and C Brown, and J L Falk
January 1974, Pharmacology, biochemistry, and behavior,
M Tang, and C Brown, and J L Falk
January 1996, The Chinese journal of physiology,
M Tang, and C Brown, and J L Falk
August 1980, Pharmacology, biochemistry, and behavior,
M Tang, and C Brown, and J L Falk
March 1972, Physiology & behavior,
M Tang, and C Brown, and J L Falk
August 1976, Psychopharmacology,
M Tang, and C Brown, and J L Falk
June 1981, Pharmacology, biochemistry, and behavior,
M Tang, and C Brown, and J L Falk
January 1974, Psychopharmacologia,
M Tang, and C Brown, and J L Falk
October 2008, Pharmacology, biochemistry, and behavior,
M Tang, and C Brown, and J L Falk
November 1987, Drug and alcohol dependence,
M Tang, and C Brown, and J L Falk
August 1973, Physiology & behavior,
Copied contents to your clipboard!