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In order to assess diurnal variation of flow-volume curves and to determine whether small airways are involved in the diurnal variation of pulmonary function in asthmatic children, we studied eight asthmatics who were attending an asthma summer camp. Spirometry and maximal expiratory flow-volume curves with air and a helium-oxygen mixture were obtained in the morning and afternoon over a 10-day period. We found that significant increases in maximal expiratory flows at all lung volumes occurred in the afternoon. However, the increase in flows with helium (helium response) was unchanged from morning to afternoon. These results suggest that both large and small airways are involved in the diurnal variation of pulmonary function in asthmatic children.
H Mak, and
B E Chipps, and
H A Menkes, and
K C Schuberth, and
J H Talamo, and
M S Scherr, and
R C Talamo, and
S Permutt
May 1980,
Minerva pediatrica,
H Mak, and
B E Chipps, and
H A Menkes, and
K C Schuberth, and
J H Talamo, and
M S Scherr, and
R C Talamo, and
S Permutt
January 1979,
Respiration; international review of thoracic diseases,
H Mak, and
B E Chipps, and
H A Menkes, and
K C Schuberth, and
J H Talamo, and
M S Scherr, and
R C Talamo, and
S Permutt
September 1984,
Chest,
H Mak, and
B E Chipps, and
H A Menkes, and
K C Schuberth, and
J H Talamo, and
M S Scherr, and
R C Talamo, and
S Permutt
April 1982,
Zhonghua jie he he hu xi xi ji bing za zhi = Chinese journal of tuberculosis and respiratory diseases,
H Mak, and
B E Chipps, and
H A Menkes, and
K C Schuberth, and
J H Talamo, and
M S Scherr, and
R C Talamo, and
S Permutt
January 1986,
Pediatric pulmonology,
H Mak, and
B E Chipps, and
H A Menkes, and
K C Schuberth, and
J H Talamo, and
M S Scherr, and
R C Talamo, and
S Permutt
January 1981,
International archives of occupational and environmental health,
H Mak, and
B E Chipps, and
H A Menkes, and
K C Schuberth, and
J H Talamo, and
M S Scherr, and
R C Talamo, and
S Permutt
January 1981,
The Journal of the Singapore Paediatric Society,
H Mak, and
B E Chipps, and
H A Menkes, and
K C Schuberth, and
J H Talamo, and
M S Scherr, and
R C Talamo, and
S Permutt
May 1977,
Kokyu to junkan. Respiration & circulation,
H Mak, and
B E Chipps, and
H A Menkes, and
K C Schuberth, and
J H Talamo, and
M S Scherr, and
R C Talamo, and
S Permutt
December 1979,
Revue francaise des maladies respiratoires,
H Mak, and
B E Chipps, and
H A Menkes, and
K C Schuberth, and
J H Talamo, and
M S Scherr, and
R C Talamo, and
S Permutt
February 1981,
The American review of respiratory disease,
