Biomaterial Database

Central nervous system effects of methyl methacrylate vapor. 1981

D L Innes, and M F Tansy

Inhalation experiments were conducted by exposing mature male Sprague-Dawley rats to methyl methacrylate (MMA) monomer vapor in air. The effects upon central neuronal activity associated with acute exposures of chloralose-urethanized rats to monomeric MMA vapor concentrations are summarized in this report. The most remarkable and readily apparent phenomenon was the depression of multiple-unit electrical activity in the lateral hypothalamus and ventral hippocampus of rats which were exposed to 400 ppm of MMA in air for 60 min. In marked contrast, recordings made from the parietal cortex, cerebellum, dorsal hippocampus, medial amygdala, ventral medial hypothalamus, anterior hypothalamus, septum, and mammillary body following comparable exposures showed insignificant changes in multiple-unit electrical activity.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008768	Methylmethacrylates	The methyl esters of methacrylic acid that polymerize easily and are used as tissue cements, dental materials, and absorbent for biological substances.
D009474	Neurons	The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.	Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D001921	Brain	The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.	Encephalon
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014835	Volatilization	A phase transition from liquid state to gas state, which is affected by Raoult's law. It can be accomplished by fractional distillation.	Vaporization,Volatility
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus