-transparent.png){kind=logo}
The effects of a new analogue of PGE1 (CL115,574) on gastric acid secretion, mucus secretion and protection against stress and indomethacin-induced ulcers were studied in the rat. CL115,574 was more potent than PGE1 and cimetidine in inhibiting acid secretion. CL115,574 protected against the development of stress and indomethacin-induced ulcers and prevented the indomethacin-induced decrease in hematocrit at an ED50 (3 micrograms/kg) far below the antisecretory ED50 (1 microgram/kg). While inhibiting acid secretion, CL115,574 increased the volume of gastric secretion indicating a stimulation of nonparietal cell secretion by the rat stomach. In addition the compound stimulated the secretion of mucus into the gastric juice. On the basis of its potency as an inhibitor of acid secretion and these additional effects which are indicative of cytoprotective activity, CL115,574 should be further studied as a possible anti-ulcer agent in man.
J E Birnbaum, and
D E Wilson, and
R Partridge, and
W Scruggs, and
A E Sloboda, and
S Mourillon
April 1989,
DICP : the annals of pharmacotherapy,
J E Birnbaum, and
D E Wilson, and
R Partridge, and
W Scruggs, and
A E Sloboda, and
S Mourillon
June 1987,
Hepato-gastroenterology,
J E Birnbaum, and
D E Wilson, and
R Partridge, and
W Scruggs, and
A E Sloboda, and
S Mourillon
September 1989,
Clinical pharmacy,
J E Birnbaum, and
D E Wilson, and
R Partridge, and
W Scruggs, and
A E Sloboda, and
S Mourillon
January 1991,
Digestion,
J E Birnbaum, and
D E Wilson, and
R Partridge, and
W Scruggs, and
A E Sloboda, and
S Mourillon
February 1990,
The Australian and New Zealand journal of surgery,
J E Birnbaum, and
D E Wilson, and
R Partridge, and
W Scruggs, and
A E Sloboda, and
S Mourillon
August 1975,
Prostaglandins,
J E Birnbaum, and
D E Wilson, and
R Partridge, and
W Scruggs, and
A E Sloboda, and
S Mourillon
November 1993,
Gastroenterology,
J E Birnbaum, and
D E Wilson, and
R Partridge, and
W Scruggs, and
A E Sloboda, and
S Mourillon
January 1985,
Arzneimittel-Forschung,
J E Birnbaum, and
D E Wilson, and
R Partridge, and
W Scruggs, and
A E Sloboda, and
S Mourillon
June 1974,
Prostaglandins,
J E Birnbaum, and
D E Wilson, and
R Partridge, and
W Scruggs, and
A E Sloboda, and
S Mourillon
October 2022,
Prostaglandins & other lipid mediators,
