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The arrhythmogenicity of epinephrine was examined in 34 male mongrel dogs awake and during 1.1 MAC steady state halothane-O2 anesthesia with the addition of 50% N2O, nitrogen, or helium. All anesthetized dogs required more epinephrine than did awake dogs to produce ventricular extrasystoles. Dogs given halothane-N2O were more sensitive to the epinephrine infusion than those given halothane-nitrogen or halothane-helium. The dogs given halothane-N2O also showed a small, but statistically significant difference from dogs given halothane-O2. These results suggest that the addition of N2O to halothane increases the cardiac arrhythmic potential of epinephrine in the dog.
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