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The carcinogenicity of sodium and of sodium nitrate was examined in F-344 rats. Sodium nitrite was administered in the drinking-water for 2 yr at levels of 0.125 or 0.25%. Sodium nitrate was given in the diet at levels 2.5 or 5%. A variety of tumours occurred in all groups including the controls. The only significant difference between treated and control groups in the total number of tumours detected in either of the studies was a significant decrease in tumour incidence in the high-dose females given nitrite compared with controls. There was no positive dose-response relationship either in the incidence or in the induction time of tumours in either of the studies. The only significant result was a reduction in the incidence of mononuclear cell leukaemias in the experimental groups in both studies. It is concluded that sodium nitrite and sodium nitrate did not exert a carcinogenic effect that could be detected under the conditions of this study in which the animals showed a high incidence of spontaneous tumours.
A Maekawa, and
T Ogiu, and
H Onodera, and
K Furuta, and
C Matsuoka, and
Y Ohno, and
S Odashima
January 1982,
Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences,
A Maekawa, and
T Ogiu, and
H Onodera, and
K Furuta, and
C Matsuoka, and
Y Ohno, and
S Odashima
April 1991,
Carcinogenesis,
A Maekawa, and
T Ogiu, and
H Onodera, and
K Furuta, and
C Matsuoka, and
Y Ohno, and
S Odashima
January 1982,
Cancer letters,
A Maekawa, and
T Ogiu, and
H Onodera, and
K Furuta, and
C Matsuoka, and
Y Ohno, and
S Odashima
April 1991,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
A Maekawa, and
T Ogiu, and
H Onodera, and
K Furuta, and
C Matsuoka, and
Y Ohno, and
S Odashima
August 2006,
The Lancet. Oncology,
A Maekawa, and
T Ogiu, and
H Onodera, and
K Furuta, and
C Matsuoka, and
Y Ohno, and
S Odashima
August 1980,
Journal of the National Cancer Institute,
A Maekawa, and
T Ogiu, and
H Onodera, and
K Furuta, and
C Matsuoka, and
Y Ohno, and
S Odashima
June 1981,
Journal of the National Cancer Institute,
A Maekawa, and
T Ogiu, and
H Onodera, and
K Furuta, and
C Matsuoka, and
Y Ohno, and
S Odashima
March 1999,
Toxicological sciences : an official journal of the Society of Toxicology,
A Maekawa, and
T Ogiu, and
H Onodera, and
K Furuta, and
C Matsuoka, and
Y Ohno, and
S Odashima
February 2000,
Japanese journal of cancer research : Gann,
A Maekawa, and
T Ogiu, and
H Onodera, and
K Furuta, and
C Matsuoka, and
Y Ohno, and
S Odashima
June 1984,
Experientia,
