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Murine lymphoid cells respond rapidly to bacterial lipopolysaccharide or antigen-antibody complexes to initiate or accelerate the blood coagulation pathways. The monocyte or macrophage has been identified as the cellular source, although lymphocyte collaboration is required for the rapid induction of the procoagulant response. This procoagulant activity is identified in the present study as a direct prothrombin activator, i.e., a prothrombinase. Studies with plasmas deficient in single coagulation factors demonstrate that the induced murine procoagulant activity effector molecule does not require factors XII, VIII, VII, X, or V, but does require prothrombin to transform fibrinogen to fibrin. This enzyme(s) produces limited proteolysis of prothrombin to yield thrombin or thrombinlike products that are functionally capable of converting fibrinogen to fibrin. The prothrombinase is undetectable in freshly isolated Murine lymphoid cells respond rapidly to bacterial lipopolysaccharide or antigen-antibody complexes to initiate or accelerate the blood coagulation pathways. The monocyte or macrophage has been identified as the cellular source, although lymphocyte collaboration is required for the rapid induction of the procoagulant response. This procoagulant activity is identified in the present study as a direct prothrombin activator, i.e., a prothrombinase. Studies with plasmas deficient in single coagulation factors demonstrate that the induced murine procoagulant activity effector molecule does not require factors XII, VIII, VII, X, or V, but does require prothrombin to transform fibrinogen to fibrin. This enzyme(s) produces limited proteolysis of prothrombin to yield thrombin or thrombinlike products that are functionally capable of converting fibrinogen to fibrin. The prothrombinase is undetectable in freshly isolated
B S Schwartz, and
G A Levy, and
D S Fair, and
T S Edgington
August 1981,
Journal of immunology (Baltimore, Md. : 1950),
B S Schwartz, and
G A Levy, and
D S Fair, and
T S Edgington
October 1993,
European journal of immunology,
B S Schwartz, and
G A Levy, and
D S Fair, and
T S Edgington
March 1982,
Journal of immunology (Baltimore, Md. : 1950),
B S Schwartz, and
G A Levy, and
D S Fair, and
T S Edgington
November 1988,
The Journal of laboratory and clinical medicine,
B S Schwartz, and
G A Levy, and
D S Fair, and
T S Edgington
March 1998,
Arteriosclerosis, thrombosis, and vascular biology,
B S Schwartz, and
G A Levy, and
D S Fair, and
T S Edgington
September 1981,
The Journal of experimental medicine,
B S Schwartz, and
G A Levy, and
D S Fair, and
T S Edgington
January 1986,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
B S Schwartz, and
G A Levy, and
D S Fair, and
T S Edgington
October 1983,
Thrombosis research,
B S Schwartz, and
G A Levy, and
D S Fair, and
T S Edgington
May 1986,
International journal of cancer,
B S Schwartz, and
G A Levy, and
D S Fair, and
T S Edgington
May 2016,
European review for medical and pharmacological sciences,
