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On the basis of controversial results from clinical use of hyperthermal irrigation of the bladder lumen published by various authors a procedure was developed for transurethral local high frequency hyperthermia using phantom experiments and experimental bladder tumors. Encouraging results from experiments on animals led to clinical use of this technique with pretreated recurring bladder tumors (n = 64) at various stages. Poorly differentiated tumors at higher stages responded especially well. Typical pathohistological findings induced by hyperthermia were in these cases extensive tumor-necroses, and as late finding stromahyalinoses. Permanent changes of tumorfree urothelium have not been observed. During the observation period up to the present (maximum 48 month) the 3-year-survival rate has been 92.5% (T1G2-3), 59.4% (T2G3) and 22.0% (T3G3).
K H Bichler, and
R Harzmann, and
G Flachenecker, and
K Fastenmeier, and
E Altenähr, and
D Gericke, and
S H Flüchter
January 1980,
Radiobiologia, radiotherapia,
K H Bichler, and
R Harzmann, and
G Flachenecker, and
K Fastenmeier, and
E Altenähr, and
D Gericke, and
S H Flüchter
January 1981,
Bulletin du cancer,
K H Bichler, and
R Harzmann, and
G Flachenecker, and
K Fastenmeier, and
E Altenähr, and
D Gericke, and
S H Flüchter
May 1977,
Der Urologe. Ausg. A,
K H Bichler, and
R Harzmann, and
G Flachenecker, and
K Fastenmeier, and
E Altenähr, and
D Gericke, and
S H Flüchter
March 1974,
Der Urologe. Ausg. A,
K H Bichler, and
R Harzmann, and
G Flachenecker, and
K Fastenmeier, and
E Altenähr, and
D Gericke, and
S H Flüchter
July 1976,
Der Urologe. Ausg. A,
K H Bichler, and
R Harzmann, and
G Flachenecker, and
K Fastenmeier, and
E Altenähr, and
D Gericke, and
S H Flüchter
January 1977,
Der Urologe. Ausg. A,
K H Bichler, and
R Harzmann, and
G Flachenecker, and
K Fastenmeier, and
E Altenähr, and
D Gericke, and
S H Flüchter
March 1977,
Journal d'urologie et de nephrologie,
K H Bichler, and
R Harzmann, and
G Flachenecker, and
K Fastenmeier, and
E Altenähr, and
D Gericke, and
S H Flüchter
January 1981,
Chirurgie; memoires de l'Academie de chirurgie,
K H Bichler, and
R Harzmann, and
G Flachenecker, and
K Fastenmeier, and
E Altenähr, and
D Gericke, and
S H Flüchter
October 1978,
Therapeutische Umschau. Revue therapeutique,
K H Bichler, and
R Harzmann, and
G Flachenecker, and
K Fastenmeier, and
E Altenähr, and
D Gericke, and
S H Flüchter
January 1982,
Der Urologe. Ausg. A,
