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A new method was developed by which the tone of bronchial smooth muscle can be measured breath by breath in man. Thereby state and reactions of bronchial smooth muscle can be studied. Former investigations had shown that carbonic anhydrase inhibitors have a broncholytic effect. The mechanism of action presumably is the prevention by carbonic anhydrase inhibitors of CO2 induced changes of pH within the bronchial epithelium occurring breath by breath with different partial pressures of CO2. Principally a stabilisation of pH can also be achieved by buffers. Therefore the broncholytic effect of buffers was tested and a 10% buffer solution of phosphat and Tris (THAM) buffer applied by inhalation in two healthy volunteers. In both cases a significant bronchodilation was seen, which in case of phosphate was substantially greater than in case of conventional broncholytics (e.g., fenoterol). As concerns onset and duration of the broncholytic effect, buffers are similar to conventional broncholytics. It is great advantage that buffers do not stimulate bronchial peristalsis and do not have cardiac side effects, contrary to conventional broncholytics.
K Diether, and
W K Barnikol
October 1974,
Therapie der Gegenwart,
K Diether, and
W K Barnikol
January 1968,
Allergie und Asthma,
K Diether, and
W K Barnikol
June 1971,
Nordisk medicin,
K Diether, and
W K Barnikol
June 1981,
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae,
K Diether, and
W K Barnikol
January 1973,
Acta tuberculosea et pneumologica Belgica,
K Diether, and
W K Barnikol
January 1979,
L'Encephale,
K Diether, and
W K Barnikol
May 1977,
MMW, Munchener medizinische Wochenschrift,
K Diether, and
W K Barnikol
June 1971,
Nordisk medicin,
K Diether, and
W K Barnikol
January 1982,
L'Encephale,
K Diether, and
W K Barnikol
January 1979,
MMW, Munchener medizinische Wochenschrift,
