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The therapeutic activity of a single-dose treatment with 14 2-chloroethylnitrosocarbamoyl derivatives of amino acids (CNU-analogs) in L 5222 rat leukemia is presented. Compounds under study included free carboxylic acids, a methylester, a toluidide, four glucosamides and one derivative of a dipeptide. All substances proved to be active effecting at least an increase in life span of greater than or equal to 120% compared with untreated controls at the optimal dose; 2 compounds effected isolated cures (90-day survivors). Compared with previous data obtained with established and new nitrosoureas under the same conditions, the effectivity of the compounds presented here should be classified, however, only as moderate.
W J Zeller, and
M Berger, and
G Eisenbrand, and
W Tang, and
D Schmähl
September 1987,
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W J Zeller, and
M Berger, and
G Eisenbrand, and
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D Schmähl
January 1981,
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W J Zeller, and
M Berger, and
G Eisenbrand, and
W Tang, and
D Schmähl
January 1978,
Arzneimittel-Forschung,
W J Zeller, and
M Berger, and
G Eisenbrand, and
W Tang, and
D Schmähl
November 1974,
Cell and tissue kinetics,
W J Zeller, and
M Berger, and
G Eisenbrand, and
W Tang, and
D Schmähl
January 1992,
Anticancer research,
W J Zeller, and
M Berger, and
G Eisenbrand, and
W Tang, and
D Schmähl
May 1977,
Blut,
W J Zeller, and
M Berger, and
G Eisenbrand, and
W Tang, and
D Schmähl
January 1975,
Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology,
W J Zeller, and
M Berger, and
G Eisenbrand, and
W Tang, and
D Schmähl
April 1974,
Blut,
W J Zeller, and
M Berger, and
G Eisenbrand, and
W Tang, and
D Schmähl
January 1993,
Anticancer research,
W J Zeller, and
M Berger, and
G Eisenbrand, and
W Tang, and
D Schmähl
August 1976,
Experientia,
