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The action of methotrexate, actinomycin D, bleomycin, vincristine and hydroxyurea on the production of human chorionic gonadotrophin (hCG) by a choriocarcinoma cell line (BeWo) has been studied. hCG production per unit of cell protein was increased, and this was a continuing process only halted by cell death. The proportion of hCG-producing cells in the population increased from approximately 5% to a maximum of approximately 40% during incubation with vincristine. A possible explanation for these and related observations is that cytotoxic agents promote the differentiation of cytotrophoblast to syncytium. A similar mechanism could contribute to the unusual sensitivity of choriocarcinoma to cytotoxic agents.
P Browne, and
K D Bagshawe
January 1973,
Annals of internal medicine,
P Browne, and
K D Bagshawe
December 1974,
British journal of cancer,
P Browne, and
K D Bagshawe
December 1989,
The Journal of endocrinology,
P Browne, and
K D Bagshawe
May 1985,
International journal of cancer,
P Browne, and
K D Bagshawe
February 1984,
Cancer,
P Browne, and
K D Bagshawe
September 1976,
The Medical journal of Australia,
P Browne, and
K D Bagshawe
September 1970,
Proceedings of the National Academy of Sciences of the United States of America,
P Browne, and
K D Bagshawe
June 1982,
Acta endocrinologica,
P Browne, and
K D Bagshawe
June 1993,
Human reproduction (Oxford, England),
