An observational analysis of the behavioural effects of beta-phenylethylamine in isolated and grouped mice. 1982

C T Dourish

1. Male Swiss mice were treated systemically with beta-phenylethylamine (PEA, 25-150 mg/kg), and observed in isolation or in groups of five. The effects of PEA were scored on 13 separate components of behaviour which were produced or increased by the drug. 2. PEA at a dose of 25 mg/kg depressed activity and caused sedation, but at 50 mg/kg produced a brief stimulation of activity. At higher dose levels (75-150 mg/kg) the compound induced a biphasic stimulation of activity which was associated with the development of two distinct groups of stereotyped activities. 3. Group testing significantly antagonized early phase stereotypy (forepaw padding, headweaving, compulsive grooming) but had no effect on, or potentiated, late phase stereotypy (rearing, licking). In addition grouped mice were more active and hyperreactive than isolated mice. 4. The results are briefly discussed in the light of the possibility of a catecholamine/indoleamine interaction in the control of the hyperactivity syndrome induced by PEA in the mouse.

UI MeSH Term Description Entries
D008297 Male Males
D009043 Motor Activity Body movements of a human or an animal as a behavioral phenomenon. Activities, Motor,Activity, Motor,Motor Activities
D009115 Muridae A family of the order Rodentia containing 250 genera including the two genera Mus (MICE) and Rattus (RATS), from which the laboratory inbred strains are developed. The fifteen subfamilies are SIGMODONTINAE (New World mice and rats), CRICETINAE, Spalacinae, Myospalacinae, Lophiomyinae, ARVICOLINAE, Platacanthomyinae, Nesomyinae, Otomyinae, Rhizomyinae, GERBILLINAE, Dendromurinae, Cricetomyinae, MURINAE (Old World mice and rats), and Hydromyinae. Murids,Murid
D010627 Phenethylamines A group of compounds that are derivatives of beta- aminoethylbenzene which is structurally and pharmacologically related to amphetamine. (From Merck Index, 11th ed) Phenylethylamines
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001522 Behavior, Animal The observable response an animal makes to any situation. Autotomy Animal,Animal Behavior,Animal Behaviors
D012931 Social Environment The aggregate of social and cultural institutions, forms, patterns, and processes that influence the life of an individual or community. Social Context,Environment, Social,Social Ecology,Context, Social,Contexts, Social,Ecologies, Social,Ecology, Social,Environments, Social,Social Contexts,Social Ecologies,Social Environments
D012934 Social Isolation The separation of individuals or groups resulting in the lack of or minimizing of social contact and/or communication. This separation may be accomplished by physical separation, by social barriers and by psychological mechanisms. In the latter, there may be interaction but no real communication. Isolation, Social,Social Exclusion,Exclusion, Social,Social Exclusions

Related Publications

C T Dourish
November 2004, Drug and alcohol dependence,
C T Dourish
January 1975, Pharmacology,
C T Dourish
January 1979, Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova,
C T Dourish
December 1968, Journal of psychiatric research,
C T Dourish
January 1971, Revista de la Sociedad Argentina de Biologia,
C T Dourish
February 1980, Biochemical pharmacology,
C T Dourish
October 1983, The Journal of pharmacology and experimental therapeutics,
C T Dourish
January 1961, The Journal of pharmacology and experimental therapeutics,
Copied contents to your clipboard!