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The effect of both centrally and peripherally acting cholinergic drugs on acute and chronic morphine dependence was investigated. The quaternary ammonium drugs, neostigmine and atropine methyl bromide which cross the blood-brain barrier with difficulty, significantly altered the withdrawal jumping and wet shakes in a similar manner to that exhibited by centrally acting tertiary drugs viz. physostigmine and atropine sulphate. The cholinergic agonists inhibited the withdrawal signs while the antagonists enhanced the same. This suggests that the peripheral cholinergic mechanisms are also involved apart from the central mechanisms in the phenomena of acute and chronic morphine dependence.
N Padmanabha Pillai, and
S Ramaswamy, and
V Gopalakrishnan, and
M N Ghosh
January 1986,
General pharmacology,
N Padmanabha Pillai, and
S Ramaswamy, and
V Gopalakrishnan, and
M N Ghosh
June 1959,
Bollettino della Societa italiana di biologia sperimentale,
N Padmanabha Pillai, and
S Ramaswamy, and
V Gopalakrishnan, and
M N Ghosh
April 1975,
The Journal of pharmacology and experimental therapeutics,
N Padmanabha Pillai, and
S Ramaswamy, and
V Gopalakrishnan, and
M N Ghosh
January 1980,
Stroke,
N Padmanabha Pillai, and
S Ramaswamy, and
V Gopalakrishnan, and
M N Ghosh
January 1969,
Indian journal of physiology and pharmacology,
N Padmanabha Pillai, and
S Ramaswamy, and
V Gopalakrishnan, and
M N Ghosh
January 1975,
Advances in biochemical psychopharmacology,
N Padmanabha Pillai, and
S Ramaswamy, and
V Gopalakrishnan, and
M N Ghosh
February 2017,
Physiology & behavior,
N Padmanabha Pillai, and
S Ramaswamy, and
V Gopalakrishnan, and
M N Ghosh
January 1987,
Neuropharmacology,
N Padmanabha Pillai, and
S Ramaswamy, and
V Gopalakrishnan, and
M N Ghosh
August 2013,
Pharmacology, biochemistry, and behavior,
N Padmanabha Pillai, and
S Ramaswamy, and
V Gopalakrishnan, and
M N Ghosh
March 1977,
Psychopharmacology,
