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Inhibition of twitch responses of the guinea-pig isolated ileum to low frequency electric stimulation (0.2 Hz) followed the interpolation of a dose of histamine left in contact for 30 sec. This post-histamine inhibition, which was dose related, was not affected by mepyramine or cimetidine and thus was not brought about by an action on known histamine receptors. Histamine also reduced the height of contractions caused by exogenous acetylcholine (ACh) and this inhibition was quantitatively similar to the degree of post-histamine inhibition of twitch recorded at corresponding times following the removal of histamine by overflow. It therefore seems likely that histamine-induced inhibition of twitch is caused by desensitisation of the postsynaptic membrane to endogenous ACh released during transmural stimulation.
P Fosbraey, and
E S Johnson, and
F F Mckay
September 1990,
European journal of pharmacology,
P Fosbraey, and
E S Johnson, and
F F Mckay
August 1978,
The Journal of pharmacology and experimental therapeutics,
P Fosbraey, and
E S Johnson, and
F F Mckay
February 1978,
The Journal of pharmacology and experimental therapeutics,
P Fosbraey, and
E S Johnson, and
F F Mckay
October 1973,
Nature: New biology,
P Fosbraey, and
E S Johnson, and
F F Mckay
November 1980,
Life sciences,
P Fosbraey, and
E S Johnson, and
F F Mckay
January 1984,
General pharmacology,
P Fosbraey, and
E S Johnson, and
F F Mckay
January 1970,
International archives of allergy and applied immunology,
P Fosbraey, and
E S Johnson, and
F F Mckay
June 1973,
British journal of pharmacology,
P Fosbraey, and
E S Johnson, and
F F Mckay
April 1988,
Agents and actions,
P Fosbraey, and
E S Johnson, and
F F Mckay
October 1979,
Naunyn-Schmiedeberg's archives of pharmacology,
