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Validity of total lung capacity determination by the single breath nitrogen technique. 1980

J Pino, and D B Teculescu

Total lung capacity (TLC) derived from the single breath oxygen test (dilution of alveolar nitrogen) was compared with the plethysmographic TLC in 40 healthy males aged 25 to 55 years and in 16 patients with chronic obstructive respiratory disease. In healthy subjects TLC02 was 8% less (P less than 0.001) than TLC pleth. The two results were highly correlated (r = 0.89; P less than 0.001); their difference tended to increase with age and correlated significantly with the slope of phase III (P less than 0.01). In patients TLC02 underestimated the lung volume by 5 to 50% (average 28%) (P less than 0.001), and the relation between the two measurements were weaker (r = 0.59; P less than 0.02). The TLC02/TLC pleth. ratio was significantly related to FEV1.0% predicted (r = 0.68) and to specific conductance (r = 0.60), and highly significantly (P less than 0.001) related to obstructive ventilatory impairment (r = 0.77), to distribution unevenness (r = -0.85) and overinflation (r = 0.94). Although an overestimation of lung volume by plethysmography in the presence of severe obstruction cannot be excluded, most of the discrepancy reported is to be ascribed to underestimation by single breath nitrogen dilution due to impaired distribution of ventilation.

UI MeSH Term Description Entries
D008168 Lung Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood. Lungs
D008173 Lung Diseases, Obstructive Any disorder marked by obstruction of conducting airways of the lung. AIRWAY OBSTRUCTION may be acute, chronic, intermittent, or persistent. Obstructive Lung Diseases,Obstructive Pulmonary Diseases,Lung Disease, Obstructive,Obstructive Lung Disease,Obstructive Pulmonary Disease,Pulmonary Disease, Obstructive,Pulmonary Diseases, Obstructive
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009584 Nitrogen An element with the atomic symbol N, atomic number 7, and atomic weight [14.00643; 14.00728]. Nitrogen exists as a diatomic gas and makes up about 78% of the earth's atmosphere by volume. It is a constituent of proteins and nucleic acids and found in all living cells.
D010991 Plethysmography Recording of change in the size of a part as modified by the circulation in it. Plethysmographies
D002908 Chronic Disease Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2). Chronic Condition,Chronic Illness,Chronically Ill,Chronic Conditions,Chronic Diseases,Chronic Illnesses,Condition, Chronic,Disease, Chronic,Illness, Chronic
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D014109 Total Lung Capacity The volume of air contained in the lungs at the end of a maximal inspiration. It is the equivalent to each of the following sums: VITAL CAPACITY plus RESIDUAL VOLUME; INSPIRATORY CAPACITY plus FUNCTIONAL RESIDUAL CAPACITY; TIDAL VOLUME plus INSPIRATORY RESERVE VOLUME plus functional residual capacity; or tidal volume plus inspiratory reserve volume plus EXPIRATORY RESERVE VOLUME plus residual volume. Lung Capacity, Total,Capacities, Total Lung,Capacity, Total Lung,Lung Capacities, Total,Total Lung Capacities

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