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A complete crossover trial was undertaken in six healthy volunteers to gain information on dose-effect responses to indobufen by assessing the intensity and duration of the effect of 3 single oral doses of the drug on platelet aggregation induced by threshold concentration of ADP and by 3 added doses of collagen. The results of the study confirm that the activity is dose-related and is reversible since 24 hours after administration it has practically disappeared. The effect of the same dose of indobufen differed significantly according to the amount of collagen added to plasma, whereas increasing doses of indobufen provoked a significantly more marked effect when the amount of inducer employed was the same.
A Vittoria, and
F Laghi Pasini, and
G L Messa, and
T Di Perri, and
G Corvi, and
L M Fuccella
April 1981,
Haematologica,
A Vittoria, and
F Laghi Pasini, and
G L Messa, and
T Di Perri, and
G Corvi, and
L M Fuccella
January 1980,
Journal of clinical pharmacology,
A Vittoria, and
F Laghi Pasini, and
G L Messa, and
T Di Perri, and
G Corvi, and
L M Fuccella
December 1981,
Haematologica,
A Vittoria, and
F Laghi Pasini, and
G L Messa, and
T Di Perri, and
G Corvi, and
L M Fuccella
June 1979,
European journal of clinical pharmacology,
A Vittoria, and
F Laghi Pasini, and
G L Messa, and
T Di Perri, and
G Corvi, and
L M Fuccella
January 1982,
Pharmatherapeutica,
A Vittoria, and
F Laghi Pasini, and
G L Messa, and
T Di Perri, and
G Corvi, and
L M Fuccella
June 1979,
European journal of clinical pharmacology,
A Vittoria, and
F Laghi Pasini, and
G L Messa, and
T Di Perri, and
G Corvi, and
L M Fuccella
January 1985,
Thrombosis research,
A Vittoria, and
F Laghi Pasini, and
G L Messa, and
T Di Perri, and
G Corvi, and
L M Fuccella
June 1989,
Thrombosis research,
A Vittoria, and
F Laghi Pasini, and
G L Messa, and
T Di Perri, and
G Corvi, and
L M Fuccella
January 1980,
Thrombosis research,
A Vittoria, and
F Laghi Pasini, and
G L Messa, and
T Di Perri, and
G Corvi, and
L M Fuccella
October 1984,
Pharmacological research communications,
