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Retention of a passive avoidance task was studied in mice given either cycloheximide or cycloheximide in combination with nicotine. Two similar experiments were conducted: In the first experiment, the effects, of these drugs were studied in inbred C57Bl/6J mice. In the second experiment, the effects of these drugs were studied in genetically heterogenous mice. Cycloheximide was found to have a deleterious effect on retention of the passive avoidance task. Larger doses of cycloheximide were found to be necessary to disrupt memory in heterogenous mice than in C57Bl/6J animals. Nicotine, when administered in conjunction with cycloheximide, abolished the memory disruptive effects of cycloheximide. The results of these experiments are discussed in terms of a time-dependent consolidation model of memory storage.
E R Stamm, and
K Schlesinger
April 1998,
Brain research,
E R Stamm, and
K Schlesinger
April 1973,
Physiology & behavior,
E R Stamm, and
K Schlesinger
January 1982,
Neurobehavioral toxicology and teratology,
E R Stamm, and
K Schlesinger
March 1976,
Pharmacology, biochemistry, and behavior,
E R Stamm, and
K Schlesinger
August 1995,
Brain research,
E R Stamm, and
K Schlesinger
November 1977,
Developmental psychobiology,
E R Stamm, and
K Schlesinger
January 1969,
Psychopharmacologia,
E R Stamm, and
K Schlesinger
May 1991,
Pharmacology, biochemistry, and behavior,
E R Stamm, and
K Schlesinger
September 2004,
The international journal of neuropsychopharmacology,
E R Stamm, and
K Schlesinger
January 2003,
Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova,
