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Neutrophil migration in patients with psoriasis vulgaris was assessed using both in vitro and in vivo techniques. In vitro chemotaxis towards endotoxin-activated serum and casein was found to be normal; however, random filter migration was increased in patients with extensive lesions. No significant difference was observed between the effects of psoriatic and normal serum on control leukocyte in vitro migration. In vivo skin window chamber random migration and chemotaxis towards 50% autologous serum were also found to be normal in uninvolved skin, regardless of disease severity. We have not been able to confirm previous reports of abnormal leukocyte chemotaxis in psoriasis, and submit that neutrophil migration into psoriatic plaques in vivo is the result of a local accumulation of chemotactic factors rather than of enhanced leukocyte chemotactic activity.
S M Breathnach, and
P Carrington, and
M M Black
August 1987,
The British journal of dermatology,
S M Breathnach, and
P Carrington, and
M M Black
April 1983,
Dermatologische Monatschrift,
S M Breathnach, and
P Carrington, and
M M Black
March 2007,
Journal of the European Academy of Dermatology and Venereology : JEADV,
S M Breathnach, and
P Carrington, and
M M Black
January 1980,
Medicina cutanea ibero-latino-americana,
S M Breathnach, and
P Carrington, and
M M Black
January 1977,
Medicina cutanea ibero-latino-americana,
S M Breathnach, and
P Carrington, and
M M Black
September 2002,
Histochemistry and cell biology,
S M Breathnach, and
P Carrington, and
M M Black
January 1987,
Acta dermato-venereologica,
S M Breathnach, and
P Carrington, and
M M Black
January 1950,
Priroda, clovek in zdravje,
S M Breathnach, and
P Carrington, and
M M Black
January 2000,
Ryoikibetsu shokogun shirizu,
