BIOMAT Database Logo BIOMAT Database Logo

Morphine depresses dorsal horn neuron responses to controlled noxious and non-noxious cutaneous stimulation. 1980

F J Einspahr, and M F Piercey

Dorsal horn neurons of unanesthetized, decerebrated, low spinal cats were excited by controlled noxious and non-noxious natural stimulation as well as by intense transcutaneous electrical stimulation. Intravenous morphine (0.3--3.0 mg/kg) depressed the spontaneous activity, the electrically evoked discharge and the response to noxious cutaneous heat (greater than 45 degree C) of nociceptive dorsal horn neurons. In those nociceptive neurons receiving convergent non-noxious inputs, morphine also depressed responses to non-noxious cutaneous air-puff stimulation. The above morphine effects were all reserved by 0.3 mg/kg of naloxone i.v. In neurons, which were purely non-nociceptive, morphine had little or no effect on either spontaneous activity or evoked responses to non-noxious stimuli. These findings suggest that: 1) morphine has a spinal site of action in which noxious as well as non-noxious inputs are decreased; and 2) there is a group of purely non-nociceptive dorsal horn neurons which are not influenced by the spinal actions of morphine.

UI MeSH Term Description Entries
D009020 Morphine The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle. Morphine Sulfate,Duramorph,MS Contin,Morphia,Morphine Chloride,Morphine Sulfate (2:1), Anhydrous,Morphine Sulfate (2:1), Pentahydrate,Oramorph SR,SDZ 202-250,SDZ202-250,Chloride, Morphine,Contin, MS,SDZ 202 250,SDZ 202250,SDZ202 250,SDZ202250,Sulfate, Morphine
D009270 Naloxone A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors. MRZ 2593-Br,MRZ-2593,Nalone,Naloxon Curamed,Naloxon-Ratiopharm,Naloxone Abello,Naloxone Hydrobromide,Naloxone Hydrochloride,Naloxone Hydrochloride Dihydride,Naloxone Hydrochloride, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer,Naloxone, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer,Narcan,Narcanti,Abello, Naloxone,Curamed, Naloxon,Dihydride, Naloxone Hydrochloride,Hydrobromide, Naloxone,Hydrochloride Dihydride, Naloxone,Hydrochloride, Naloxone,MRZ 2593,MRZ 2593 Br,MRZ 2593Br,MRZ2593,Naloxon Ratiopharm
D009475 Neurons, Afferent Neurons which conduct NERVE IMPULSES to the CENTRAL NERVOUS SYSTEM. Afferent Neurons,Afferent Neuron,Neuron, Afferent
D010146 Pain An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS. Suffering, Physical,Ache,Pain, Burning,Pain, Crushing,Pain, Migratory,Pain, Radiating,Pain, Splitting,Aches,Burning Pain,Burning Pains,Crushing Pain,Crushing Pains,Migratory Pain,Migratory Pains,Pains, Burning,Pains, Crushing,Pains, Migratory,Pains, Radiating,Pains, Splitting,Physical Suffering,Physical Sufferings,Radiating Pain,Radiating Pains,Splitting Pain,Splitting Pains,Sufferings, Physical
D010812 Physical Stimulation Act of eliciting a response from a person or organism through physical contact. Stimulation, Physical,Physical Stimulations,Stimulations, Physical
D002415 Cats The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801) Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D004558 Electric Stimulation Use of electric potential or currents to elicit biological responses. Stimulation, Electric,Electrical Stimulation,Electric Stimulations,Electrical Stimulations,Stimulation, Electrical,Stimulations, Electric,Stimulations, Electrical
D006358 Hot Temperature Presence of warmth or heat or a temperature notably higher than an accustomed norm. Heat,Hot Temperatures,Temperature, Hot,Temperatures, Hot
D000200 Action Potentials Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli. Spike Potentials,Nerve Impulses,Action Potential,Impulse, Nerve,Impulses, Nerve,Nerve Impulse,Potential, Action,Potential, Spike,Potentials, Action,Potentials, Spike,Spike Potential
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

F J Einspahr, and M F Piercey
Etomidate depresses lumbar dorsal horn neuronal responses to noxious thermal stimulation in rats.
April 2006, Anesthesia and analgesia,
F J Einspahr, and M F Piercey
Propofol directly depresses lumbar dorsal horn neuronal responses to noxious stimulation in goats.
March 2000, Canadian journal of anaesthesia = Journal canadien d'anesthesie,
F J Einspahr, and M F Piercey
Thiopental directly depresses lumbar dorsal horn neuronal responses to noxious mechanical stimulation in goats.
August 2001, Acta anaesthesiologica Scandinavica,
F J Einspahr, and M F Piercey
Responses of spinal cord dorsal horn neurones to non-noxious and noxious cutaneous temperature changes in the spinal rat.
June 1979, Pain,
F J Einspahr, and M F Piercey
Meloxicam selectively depresses the afterdischarge of rat spinal dorsal horn neurones in response to noxious stimulation.
June 2001, Neuroscience letters,
F J Einspahr, and M F Piercey
Effects of morphine sulfate on dorsal-horn neuronal responses to graded noxious thermal stimulation in the decerebrate cat.
November 1979, Anesthesiology,
F J Einspahr, and M F Piercey
A comparative study of selective stimulation of raphe nuclei in the cat in inhibiting dorsal horn neuron responses to noxious stimulation.
December 1981, Brain research,
F J Einspahr, and M F Piercey
Habenular neuron responses to noxious input are modified by dorsal raphe stimulation.
June 1990, Neurological research,
F J Einspahr, and M F Piercey
The effects of aromatic anesthetics on dorsal horn neuronal responses to noxious stimulation.
June 2008, Anesthesia and analgesia,
F J Einspahr, and M F Piercey
Pharmacological differentiation between responses of rat medullary dorsal horn neurons to noxious mechanical and noxious thermal cutaneous stimuli.
March 1983, Brain research,
Copied contents to your clipboard!