-transparent.png){kind=logo}
Parathyroid hormone (PTH) and its N-terminal 1-34 fragment were shown to be hypotensive in dogs. In this study, synthetic bovine PTH fragments containing the N-terminal amino acids 1-34, 24-34, 24-28 and 25-27 [bPTH-(1-34), bPTH-(24-34), bPTH-(24-28) and bPTH-(24-27)] were synthesized and tested for hypotensive activity in dogs. bPTH-(1-34) is the most potent of these. The tripeptide is ineffective at doses as high as 2 mg/kg. bPTH-(24-34) and bPTH-(24-28) exhibited hypotensive activity but were less effective than bPTH-(1-34). A decrease in chain length decreased the hypotensive activity. The maximum response produced by bPTH-(1-34) was greater than that of either bPTH-(24-34) or bPTH-(24-28). The maximum responses, however, of bPTH-(24-34) and bPTH-(24-28) were similar. Another striking difference between bPTH-(1-34) and the other two effective fragments was the duration of action. Whereas the action of bPTH-(1-34) at ED50 lasted for up to 6 min the action of bPTH-(24-34) and bPTH-(24-28) lasted for less than 1 min. The hypotensive effect of these three bPTH fragments was not affected by propranolol, phentolamine, atropine, promethazine or cimetidine. In the perfused rat hindlimb, bPTH-(24-28) produced log dose-related sustained vasodilation.
P K Pang, and
M C Yang, and
T E Tenner, and
J K Chang, and
M Shimizu
November 1981,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
P K Pang, and
M C Yang, and
T E Tenner, and
J K Chang, and
M Shimizu
March 1997,
Calcified tissue international,
P K Pang, and
M C Yang, and
T E Tenner, and
J K Chang, and
M Shimizu
May 1984,
The American journal of physiology,
P K Pang, and
M C Yang, and
T E Tenner, and
J K Chang, and
M Shimizu
December 1987,
Science (New York, N.Y.),
P K Pang, and
M C Yang, and
T E Tenner, and
J K Chang, and
M Shimizu
June 1988,
Hypertension (Dallas, Tex. : 1979),
P K Pang, and
M C Yang, and
T E Tenner, and
J K Chang, and
M Shimizu
January 1980,
The Journal of clinical endocrinology and metabolism,
P K Pang, and
M C Yang, and
T E Tenner, and
J K Chang, and
M Shimizu
December 1974,
Clinical science and molecular medicine,
P K Pang, and
M C Yang, and
T E Tenner, and
J K Chang, and
M Shimizu
August 1981,
Endocrinologia japonica,
P K Pang, and
M C Yang, and
T E Tenner, and
J K Chang, and
M Shimizu
July 2005,
Current opinion in nephrology and hypertension,
P K Pang, and
M C Yang, and
T E Tenner, and
J K Chang, and
M Shimizu
August 1989,
Naunyn-Schmiedeberg's archives of pharmacology,
