Biomaterial Database

High frequency of HLA-B27 and Reiter's syndrome in Navajo Indians. 1980

H G Morse, and R G Rate, and M D Bonnell, and T Kuberski

Eighteen cases of Reiter's syndrome were found in a population of approximately 6,000 Navajo Indians. The phenotype frequency of HLA-B27 in this population was found to be 36%. The area in which these people live is endemic for shigellosis, Shigella flexneri being the most common species isolated. Presumably the high frequency of HLA-B27 and shigella infections account for the high incidence and prevalence of Reiter's syndrome in this population.

UI	MeSH Term	Description	Entries
D007198	Indians, North American	Members of indigenous North American populations with pre-colonial contact origins.	Amerinds, North American,Indigenous North Americans,American Indian, North,American, Indigenous North,Amerind, North American,Indian, North American,Indigenous North American,North American Amerind,North American Amerinds,North American Indian,North American Indians,North American, Indigenous
D008297	Male		Males
D005260	Female		Females
D006680	HLA Antigens	Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.	Human Leukocyte Antigen,Human Leukocyte Antigens,Leukocyte Antigens,HL-A Antigens,Antigen, Human Leukocyte,Antigens, HL-A,Antigens, HLA,Antigens, Human Leukocyte,Antigens, Leukocyte,HL A Antigens,Leukocyte Antigen, Human,Leukocyte Antigens, Human
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001130	Arizona	State of the UNITED STATES OF AMERICA bounded on the east by New Mexico, on the north by Utah, on the west by Nevada and California, and on the south by Mexico.
D016918	Arthritis, Reactive	An aseptic, inflammatory arthritis developing secondary to a primary extra-articular infection, most typically of the GASTROINTESTINAL TRACT or UROGENITAL SYSTEM. The initiating trigger pathogens are usually SHIGELLA; SALMONELLA; YERSINIA; CAMPYLOBACTER; or CHLAMYDIA TRACHOMATIS. Reactive arthritis is strongly associated with HLA-B27 ANTIGEN.	Arthritis, Postinfectious,Arthritis, Post-Infectious,Post-Infectious Arthritis,Postinfectious Arthritis,Reactive Arthritis,Reiter Disease,Reiter Syndrome,Reiter's Disease,Reiter's Syndrome,Arthritis, Post Infectious,Post Infectious Arthritis,Post-Infectious Arthritides,Postinfectious Arthritides,Reactive Arthritides,Reiters Disease,Reiters Syndrome