BIOMAT Database Logo BIOMAT Database Logo

Negro alpha-thalassaemia: genetic studies in homozygous sickle cell disease. 1980

G R Serjeant, and K P Mason, and B E Serjeant

Interaction with the alpha-thalassaemia phenotypes lowers the proportion of Hb S in the sickle cell trait and influences the mean cell volume and proportional Hb A2 in homozygous sickle cell (SS) disease. By assigning somewhat arbitrary values to the alpha-thalassaemia 1 and alpha-thalassaemia 2 phenotypes in these conditions, it has been possible to investigate the patterns of inheritance of alpha-thalassaemia in black populations. The results strongly support the hypothesis that the alpha-thalassaemia 1 phenotype represents homozygosity for alpha-thalassaemia 2.

UI MeSH Term Description Entries
D007563 Jamaica An island in the Greater Antilles in the West Indies. Its capital is Kingston. It was discovered in 1494 by Columbus and was a Spanish colony 1509-1655 until captured by the English. Its flourishing slave trade was abolished in the 19th century. It was a British colony 1655-1958 and a territory of the West Indies Federation 1958-62. It achieved full independence in 1962. The name is from the Arawak Xaymaca, rich in springs or land of springs. (From Webster's New Geographical Dictionary, 1988, p564 & Room, Brewer's Dictionary of Names, 1992, p267)
D008957 Models, Genetic Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment. Genetic Models,Genetic Model,Model, Genetic
D010641 Phenotype The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment. Phenotypes
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D005808 Genes, Recessive Genes that influence the PHENOTYPE only in the homozygous state. Conditions, Recessive Genetic,Genetic Conditions, Recessive,Recessive Genetic Conditions,Condition, Recessive Genetic,Gene, Recessive,Genetic Condition, Recessive,Recessive Gene,Recessive Genes,Recessive Genetic Condition
D006580 Genetic Carrier Screening Identification of individuals who are heterozygous at a GENETIC LOCUS for a recessive PHENOTYPE. Carriers, Genetic, Detection,Genetic Carriers, Detection,Heterozygote Detection,Carrier Detection, Genetic,Detection, Genetic Carrier,Genetic Carrier Detection,Heterozygote Screening,Carrier Screening, Genetic,Detection, Heterozygote,Screening, Genetic Carrier,Screening, Heterozygote,Screenings, Genetic Carrier
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000755 Anemia, Sickle Cell A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S. Hemoglobin S Disease,HbS Disease,Sickle Cell Anemia,Sickle Cell Disease,Sickle Cell Disorders,Sickling Disorder Due to Hemoglobin S,Anemias, Sickle Cell,Cell Disease, Sickle,Cell Diseases, Sickle,Cell Disorder, Sickle,Cell Disorders, Sickle,Disease, Hemoglobin S,Hemoglobin S Diseases,Sickle Cell Anemias,Sickle Cell Diseases,Sickle Cell Disorder
D013789 Thalassemia A group of hereditary hemolytic anemias in which there is decreased synthesis of one or more hemoglobin polypeptide chains. There are several genetic types with clinical pictures ranging from barely detectable hematologic abnormality to severe and fatal anemia. Thalassemias
D044383 Black People Persons having origins in any of the black racial groups of AFRICA. Note that OMB category BLACK OR AFRICAN AMERICAN is available for the United States population groups. Race and ethnicity terms, as used in the federal government, are self-identified social construct and may include terms outdated and offensive in MeSH to assist users who are interested in retrieving comprehensive search results for studies such as in longitudinal studies. African Continental Ancestry Group,Black Person,Negroid Race,Black Peoples,Black Persons,Negroid Races,People, Black,Person, Black,Persons, Black,Race, Negroid

Related Publications

G R Serjeant, and K P Mason, and B E Serjeant
Alpha thalassaemia and the macular vasculature in homozygous sickle cell disease.
November 1983, The British journal of ophthalmology,
G R Serjeant, and K P Mason, and B E Serjeant
Influence of alpha thalassaemia on the retinopathy of homozygous sickle cell disease.
February 1993, The British journal of ophthalmology,
G R Serjeant, and K P Mason, and B E Serjeant
Acute splenic sequestration in Jamaican adults with homozygous sickle cell disease: a role of alpha thalassaemia.
April 1991, British journal of haematology,
G R Serjeant, and K P Mason, and B E Serjeant
Alpha thalassemia and homozygous sickle cell disease.
January 1981, Progress in clinical and biological research,
G R Serjeant, and K P Mason, and B E Serjeant
Genetic lesion in homozygous alpha thalassaemia (hydrops fetalis).
October 1974, Nature,
G R Serjeant, and K P Mason, and B E Serjeant
[Genetic modifiers of homozygous sickle cell disease].
January 2006, Klinische Padiatrie,
G R Serjeant, and K P Mason, and B E Serjeant
Alpha thalassaemia in Yemeni children with sickle cell disease.
December 1999, Journal of tropical pediatrics,
G R Serjeant, and K P Mason, and B E Serjeant
Alpha-thalassaemia in Nigeria: its interaction with sickle-cell disease.
April 1987, European journal of haematology,
G R Serjeant, and K P Mason, and B E Serjeant
Pattern for alpha-thalassaemia in Yemeni sickle-cell-disease patients.
November 1999, Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit,
G R Serjeant, and K P Mason, and B E Serjeant
Interaction of alpha-thalassemia and homozygous sickle-cell disease.
November 1982, The New England journal of medicine,
Copied contents to your clipboard!