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The cardioselective betablocking agent metoprolol was used to treat 21 outpatients with essential arterial hypertension graded 1 and 2 of the OMS scale. The treatment was given orally for a mean duration of nine weeks at doses of 100 mg/day for two weeks and 200 mg/day for the remaining time. The treatment caused a significant reduction of systolic and diastolic arterial pressure (p less than 0.001), both in the erect and the lying down position. The heart rate was also significantly reduced both in the lying down (p less than 0.01) and the erect (p less than 0.05) positions. Metoprolol was shown to be effective and well tolerated as an antihypertensive agent; the treatment had to be interrupted in a single case because of dizziness, tiredness and dullness.
M Salgueiro Rodríguez, and
S Pérez Pombo, and
E Beiras García
September 1973,
Munchener medizinische Wochenschrift (1950),
M Salgueiro Rodríguez, and
S Pérez Pombo, and
E Beiras García
January 2003,
Kardiologiia,
M Salgueiro Rodríguez, and
S Pérez Pombo, and
E Beiras García
September 1980,
Deutsche medizinische Wochenschrift (1946),
M Salgueiro Rodríguez, and
S Pérez Pombo, and
E Beiras García
October 1976,
Deutsche medizinische Wochenschrift (1946),
M Salgueiro Rodríguez, and
S Pérez Pombo, and
E Beiras García
January 1990,
La Clinica terapeutica,
M Salgueiro Rodríguez, and
S Pérez Pombo, and
E Beiras García
April 1986,
Journal of hypertension. Supplement : official journal of the International Society of Hypertension,
M Salgueiro Rodríguez, and
S Pérez Pombo, and
E Beiras García
March 1975,
Deutsche medizinische Wochenschrift (1946),
M Salgueiro Rodríguez, and
S Pérez Pombo, and
E Beiras García
April 1977,
L'union medicale du Canada,
M Salgueiro Rodríguez, and
S Pérez Pombo, and
E Beiras García
August 1981,
Nihon Jinzo Gakkai shi,
M Salgueiro Rodríguez, and
S Pérez Pombo, and
E Beiras García
May 1981,
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine,
