Biomaterial Database

[Familial incidence of bird-breeder's lung and HLA (author's transl)]. 1981

F Morell, and J Morera, and R Orriols, and J Mercader, and A Aranda

The cases of two siblings affected with bird-breeder's lung are reported. The analysis of their HLA group demonstrated that both belonged to the haplotype HLA Bw15. The finding of a familial incidence of this type of alveolitis favors the presence of a genetic susceptibility for the disease. The same HLA group has been found in the rare families heretofore reported with bird-breeder's lung. Given that the pathogenesis of extrinsic allergic alveolitis has recently been linked to cellular immunity (T cells), and that the presence of a common HLA haplotype in patients suffering from bird-breeder's lung is related to the capacity for an immune response in general, and to the cellular immune response in particular, the presence of a genetic susceptibility in this disease appears as very likely, although the influence of other factors can not be ruled out.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D004198	Disease Susceptibility	A constitution or condition of the body which makes the tissues react in special ways to certain extrinsic stimuli and thus tends to make the individual more than usually susceptible to certain diseases.	Diathesis,Susceptibility, Disease,Diatheses,Disease Susceptibilities,Susceptibilities, Disease
D005260	Female		Females
D006680	HLA Antigens	Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.	Human Leukocyte Antigen,Human Leukocyte Antigens,Leukocyte Antigens,HL-A Antigens,Antigen, Human Leukocyte,Antigens, HL-A,Antigens, HLA,Antigens, Human Leukocyte,Antigens, Leukocyte,HL A Antigens,Leukocyte Antigen, Human,Leukocyte Antigens, Human
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000542	Alveolitis, Extrinsic Allergic	A common interstitial lung disease caused by hypersensitivity reactions of PULMONARY ALVEOLI after inhalation of and sensitization to environmental antigens of microbial, animal, or chemical sources. The disease is characterized by lymphocytic alveolitis and granulomatous pneumonitis.	Allergic Alveolitis, Extrinsic,Hypersensitivity Pneumonitis,Pneumonitis, Hypersensitivity,Allergic Alveolitides, Extrinsic,Alveolitides, Extrinsic Allergic,Extrinsic Allergic Alveolitides,Extrinsic Allergic Alveolitis,Hypersensitivity Pneumonitides,Pneumonitides, Hypersensitivity
D001716	Bird Fancier's Lung	A form of alveolitis or pneumonitis due to an acquired hypersensitivity to inhaled avian antigens, usually proteins in the dust of bird feathers and droppings.	Avian Hypersensitivity Pneumonitis,Budgerigar Fancier's Lung,Feather Duvet Lung,Hypersensitivity Pneumonitis, Avian,Pigeon Breeder's Lung,Pneumonitis, Hypersensitivity, Avian,Pneumonitis, Avian Hypersensitivity,Avian Hypersensitivity Pneumonitides,Bird Fancier Lung,Bird Fancier's Lungs,Bird Fanciers Lung,Budgerigar Fancier Lung,Budgerigar Fancier's Lungs,Budgerigar Fanciers Lung,Duvet Lung, Feather,Duvet Lungs, Feather,Feather Duvet Lungs,Hypersensitivity Pneumonitides, Avian,Lung, Bird Fancier's,Lung, Budgerigar Fancier's,Lung, Feather Duvet,Lung, Pigeon Breeder's,Lungs, Bird Fancier's,Lungs, Budgerigar Fancier's,Lungs, Feather Duvet,Lungs, Pigeon Breeder's,Pigeon Breeder Lung,Pigeon Breeder's Lungs,Pigeon Breeders Lung,Pneumonitides, Avian Hypersensitivity