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Normal subjects and patients with adult-onset diabetes received 10 gm. of aspirin in four days. On the fourth day, the fasting serum glucose and the glucose response to oral glucose were decreased in both groups. These changes were associated with increased levels of serum insulin and pancreatic glucagon, although the glucagon responses to oral glucose were unchanged. In the diabetic patients, aspirin therapy was followed by a decreased glucose response to I.V. glucose and by the appearance of an early insulin peak, which could not be demonstrated before treatment. Aspirin did not affect the I.V. glucose tolerance in normal subjects, although it did enhance the early insulin peak. A decrease in the fasting levels of free fatty acids was noted in both groups, whereas the fasting level of triglycerides decreased only in the diabetic patients. Cholesterolemia did not change in either group. A few preliminary observations indicate that, in normal subjects, ibuprofen and ketoprofen, two other presumed prostaglandin inhibitors, did not affect fasting glycemia, glucose tolerance, or the insulin response to glucose. No changes were noted after the administration of placebo.
P Micossi, and
A E Pontiroli, and
S H Baron, and
R C Tamayo, and
F Lengel, and
M Bevilacqua, and
U Raggi, and
G Norbiato, and
P P Foà
June 1975,
The Tohoku journal of experimental medicine,
P Micossi, and
A E Pontiroli, and
S H Baron, and
R C Tamayo, and
F Lengel, and
M Bevilacqua, and
U Raggi, and
G Norbiato, and
P P Foà
May 1975,
Metabolism: clinical and experimental,
P Micossi, and
A E Pontiroli, and
S H Baron, and
R C Tamayo, and
F Lengel, and
M Bevilacqua, and
U Raggi, and
G Norbiato, and
P P Foà
January 1995,
Digestion,
P Micossi, and
A E Pontiroli, and
S H Baron, and
R C Tamayo, and
F Lengel, and
M Bevilacqua, and
U Raggi, and
G Norbiato, and
P P Foà
June 1969,
The American journal of the medical sciences,
P Micossi, and
A E Pontiroli, and
S H Baron, and
R C Tamayo, and
F Lengel, and
M Bevilacqua, and
U Raggi, and
G Norbiato, and
P P Foà
October 1975,
Diabetes,
P Micossi, and
A E Pontiroli, and
S H Baron, and
R C Tamayo, and
F Lengel, and
M Bevilacqua, and
U Raggi, and
G Norbiato, and
P P Foà
August 1990,
Zhonghua yi xue za zhi = Chinese medical journal; Free China ed,
P Micossi, and
A E Pontiroli, and
S H Baron, and
R C Tamayo, and
F Lengel, and
M Bevilacqua, and
U Raggi, and
G Norbiato, and
P P Foà
September 1995,
The American journal of physiology,
P Micossi, and
A E Pontiroli, and
S H Baron, and
R C Tamayo, and
F Lengel, and
M Bevilacqua, and
U Raggi, and
G Norbiato, and
P P Foà
August 2014,
Schizophrenia research,
P Micossi, and
A E Pontiroli, and
S H Baron, and
R C Tamayo, and
F Lengel, and
M Bevilacqua, and
U Raggi, and
G Norbiato, and
P P Foà
February 1998,
Diabetes care,
P Micossi, and
A E Pontiroli, and
S H Baron, and
R C Tamayo, and
F Lengel, and
M Bevilacqua, and
U Raggi, and
G Norbiato, and
P P Foà
January 2017,
BMJ open diabetes research & care,
