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Two rat lines selectively bred for ethanol-induced depression of locomotor activity were studied for ethanol-induced analgesia. The effects of ethanol on startle amplitude, extent of overt movements and incidence of audible vocalizations in response to intermittent, noncontingent foot shock. All three responses were dose-dependently depressed by ethanol (0.66 to 2.0 g/kg, IP), and to greater extent in the "most affected" line (MA) than in "least affected" (LA) rats. Ethanol-induced response decrements were reinstated at higher shock intensities, indicating a sensory (i.e., analgesic) rather than a motoric or analgesic basis for these effects. Genes which influence ethanol's motoric effects might, in part, influence sensitivity to its sensory effects.
H J Friedman, and
M B Bass, and
D Lester
January 1985,
Psychopharmacology,
H J Friedman, and
M B Bass, and
D Lester
November 1985,
Behavioral and neural biology,
H J Friedman, and
M B Bass, and
D Lester
August 1998,
Pharmacology, biochemistry, and behavior,
H J Friedman, and
M B Bass, and
D Lester
June 1993,
Alcoholism, clinical and experimental research,
H J Friedman, and
M B Bass, and
D Lester
January 1983,
Psychopharmacology,
H J Friedman, and
M B Bass, and
D Lester
March 1991,
Alcoholism, clinical and experimental research,
H J Friedman, and
M B Bass, and
D Lester
March 1994,
Pharmacology, biochemistry, and behavior,
H J Friedman, and
M B Bass, and
D Lester
January 1995,
Proceedings of the Western Pharmacology Society,
H J Friedman, and
M B Bass, and
D Lester
December 2006,
Behavioral neuroscience,
H J Friedman, and
M B Bass, and
D Lester
January 1981,
British journal of anaesthesia,
