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In 80 wistar rats were investigated the prolonged action of Angiotensin II in a dosage of 0,05 mg/kg/die ip. appl. on macrostructures of brain. We tested the material 1-, 3-, 7-, 14- and 21 days after the first application. In correlation with duration of the Angiotensin II action a hydroencephalie was produced. This was marked by a lumen, so big as a 1/4-1/5 of the whole brain extent. Further we observed a considerable atrophy of brain structures, particularly in the corpus callosum and the white and gray Substance of cortex. Light-microscopically we would prove edemas perivasculary with separations of ependymal cells. Conceivable mechanisms were discussed.
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