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Prostaglandin E2 and F2 alpha were measured in ejaculates from 10 fertile and 55 infertile men. Prostaglandin F2 alpha was negatively correlated with motility (r = 0.77; p less than 0.01) in normal men. In patients with disturbed fertility, prostaglandin F2 alpha was always higher than in the controls, while prostaglandin E2 was elevated only in patients with persisting varicocele and in those with very low sperm counts and severely impaired motility. There was neither de novo synthesis of prostaglandins in spermatozoa nor were binding sites for prostaglandin E2 and F2 alpha detectable. Inactivation of seminal prostaglandins by incubation with prostaglandin 15-hydroxydehydrogenase resulted in a dramatic fall in motility. The results suggest that prostaglandin F2 alpha act on motility, but the action is not mediated by receptors.
W Schlegel, and
S Rotermund, and
G Färber, and
E Nieschlag
January 1977,
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W Schlegel, and
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E Nieschlag
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W Schlegel, and
S Rotermund, and
G Färber, and
E Nieschlag
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W Schlegel, and
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E Nieschlag
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W Schlegel, and
S Rotermund, and
G Färber, and
E Nieschlag
September 2013,
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W Schlegel, and
S Rotermund, and
G Färber, and
E Nieschlag
December 1973,
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W Schlegel, and
S Rotermund, and
G Färber, and
E Nieschlag
August 2007,
Zhonghua nan ke xue = National journal of andrology,
W Schlegel, and
S Rotermund, and
G Färber, and
E Nieschlag
January 2022,
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W Schlegel, and
S Rotermund, and
G Färber, and
E Nieschlag
October 2002,
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W Schlegel, and
S Rotermund, and
G Färber, and
E Nieschlag
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