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Several new 3-thio-1,2,4-triazine derivatives were synthesized and investigated for antimicrobial and antitumor activity in in vitro and in vivo systems. Some of the investigated compounds inhibited growth of gram-positive bacteria and fungi at the concentration of 5-20 microgram/ml. Two methyl-nitro-imidazole-triazine derivatives (XI and XIII) inhibited the development of chicken fibroblast at 0.1 microgram/ml. Three out of fourteen compounds tested (V, XII and XIII) inhibited by 75% growth of sarcoma 180 when injected s.c. for 14 consecutive days in the doses of 50 and 100 mg/kg. At the same doses no effect was noted on leukemia L 1210 and P 388. Correlation between chemical structure, cytotoxic activity, antitumor effect and antimicrobial activity is discussed.
M Mordarski, and
J Wieczorek, and
L Fiszer, and
P Nantka-Namirski, and
A Rykowski
October 2004,
Farmaco (Societa chimica italiana : 1989),
M Mordarski, and
J Wieczorek, and
L Fiszer, and
P Nantka-Namirski, and
A Rykowski
January 2004,
Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina,
M Mordarski, and
J Wieczorek, and
L Fiszer, and
P Nantka-Namirski, and
A Rykowski
August 2020,
Molecules (Basel, Switzerland),
M Mordarski, and
J Wieczorek, and
L Fiszer, and
P Nantka-Namirski, and
A Rykowski
May 2008,
European journal of medicinal chemistry,
M Mordarski, and
J Wieczorek, and
L Fiszer, and
P Nantka-Namirski, and
A Rykowski
February 1988,
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
M Mordarski, and
J Wieczorek, and
L Fiszer, and
P Nantka-Namirski, and
A Rykowski
May 2023,
ACS medicinal chemistry letters,
M Mordarski, and
J Wieczorek, and
L Fiszer, and
P Nantka-Namirski, and
A Rykowski
November 2014,
Bioorganic & medicinal chemistry,
M Mordarski, and
J Wieczorek, and
L Fiszer, and
P Nantka-Namirski, and
A Rykowski
July 1999,
Die Pharmazie,
M Mordarski, and
J Wieczorek, and
L Fiszer, and
P Nantka-Namirski, and
A Rykowski
March 1988,
Die Pharmazie,
M Mordarski, and
J Wieczorek, and
L Fiszer, and
P Nantka-Namirski, and
A Rykowski
October 1992,
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
