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A pair of eyes with congenital glaucoma, one treated by goniotomy, was examined by light and electron microscopy. Examination of the drainage angles afforded the opportunity to compare anatomic changes in the treated eye with the surgically unaltered tissue of the fellow eye. The congenital glaucoma appeared to arise from compression of the trabecular meshwork and closure of the intertrabecular and transtrabecular spaces by a discontinuous "membrane" consisting of ectopic trabecular pillars that bridged the drainage angle from the iris root to the normally positioned uveal meshwork. Cleavage of trabecular pillars during goniotomy and conversion of angle architecture to that of a nonglaucomatous neonatal eye suggest that aberrant or ectopic trabecular pillars acted mechanically in maintaining angle compression. The uveal and corneoscleral meshwork and Schlemm's canal are present and appear normal.
W L Broughton, and
B S Fine, and
L E Zimmerman
November 1988,
American journal of ophthalmology,
W L Broughton, and
B S Fine, and
L E Zimmerman
April 1990,
American journal of medical genetics,
W L Broughton, and
B S Fine, and
L E Zimmerman
June 2007,
Ophthalmic genetics,
W L Broughton, and
B S Fine, and
L E Zimmerman
April 1992,
Acta ophthalmologica,
W L Broughton, and
B S Fine, and
L E Zimmerman
January 1974,
Transactions - American Academy of Ophthalmology and Otolaryngology. American Academy of Ophthalmology and Otolaryngology,
W L Broughton, and
B S Fine, and
L E Zimmerman
October 1957,
Maandschrift voor kindergeneeskunde,
W L Broughton, and
B S Fine, and
L E Zimmerman
October 1975,
Southern medical journal,
W L Broughton, and
B S Fine, and
L E Zimmerman
January 2006,
Servir (Lisbon, Portugal),
W L Broughton, and
B S Fine, and
L E Zimmerman
March 2005,
Ophthalmic genetics,
W L Broughton, and
B S Fine, and
L E Zimmerman
February 2013,
Lancet (London, England),
