-transparent.png){kind=logo}
Evidence is presented for the biochemical diagnosis of the first case of feline mannosidosis. A marked deficiency of acidic alpha-D-mannosidase in the brain, kidney and liver and excessive excretion of mannose-rich oligosaccharides in the urine were found in a kitten suffering from a nervous disorder. Residual acidic alpha-D-mannosidase, ranging from 2 to 5.5% of the normal activity, was observed in the tissues of the affected kitten. It has similar kinetic and physicochemical properties to the normal activity. The amount of mannose in the urine of the affected kitten was 19-fold greater than in a comparable control, and the molar ratio of mannose to N-acetylglucosamine was approx. 6 : 1. High concentrations of neutral oligosaccharides were detected in the urine. The predominant oligosaccharide appeared to be a hexasaccharide. The biochemical features of bovine, feline and human mannosidosis are compared, and it is concluded that feline mannosidosis may be a useful animal model for studying the human disease.
L J Burditt, and
K Chotai, and
S Hirani, and
P G Nugent, and
B G Winchester, and
W F Blakemore
December 1976,
Pediatric research,
L J Burditt, and
K Chotai, and
S Hirani, and
P G Nugent, and
B G Winchester, and
W F Blakemore
January 1992,
Virchows Archiv. B, Cell pathology including molecular pathology,
L J Burditt, and
K Chotai, and
S Hirani, and
P G Nugent, and
B G Winchester, and
W F Blakemore
January 1988,
Journal of inherited metabolic disease,
L J Burditt, and
K Chotai, and
S Hirani, and
P G Nugent, and
B G Winchester, and
W F Blakemore
November 1990,
Research in veterinary science,
L J Burditt, and
K Chotai, and
S Hirani, and
P G Nugent, and
B G Winchester, and
W F Blakemore
May 1976,
The Journal of pediatrics,
L J Burditt, and
K Chotai, and
S Hirani, and
P G Nugent, and
B G Winchester, and
W F Blakemore
January 1986,
FEBS letters,
L J Burditt, and
K Chotai, and
S Hirani, and
P G Nugent, and
B G Winchester, and
W F Blakemore
December 1977,
Archives of disease in childhood,
L J Burditt, and
K Chotai, and
S Hirani, and
P G Nugent, and
B G Winchester, and
W F Blakemore
January 1975,
Birth defects original article series,
L J Burditt, and
K Chotai, and
S Hirani, and
P G Nugent, and
B G Winchester, and
W F Blakemore
February 1993,
Anales espanoles de pediatria,
L J Burditt, and
K Chotai, and
S Hirani, and
P G Nugent, and
B G Winchester, and
W F Blakemore
January 1981,
Acta neuropathologica,
