-transparent.png){kind=logo}
X-ray diffraction studies were made on lecithin/cholesterol multilayers with very high water content and containing the local anaesthetic procaine. Narrow-angle diffraction experiments show that the procaine molecules are located with the uncharged aromatic amine group approx. 10 A from the centre of the bilayer. The polar tertiary amine group of these molecules is almost certainly located in the polar head-group region of the membrane. Wide-angle diffraction experiments show that the incorporation of procaine molecules into such lipid membranes produces an approx. 30% increase in the spread of acyl chain separation, although the average spacing between the chains is slightly reduced.
H G Coster, and
V J James, and
C Berthet, and
A Miller
April 1968,
Biochimica et biophysica acta,
H G Coster, and
V J James, and
C Berthet, and
A Miller
January 1976,
Journal of molecular biology,
H G Coster, and
V J James, and
C Berthet, and
A Miller
January 2015,
Advances in experimental medicine and biology,
H G Coster, and
V J James, and
C Berthet, and
A Miller
June 2005,
Physical review. E, Statistical, nonlinear, and soft matter physics,
H G Coster, and
V J James, and
C Berthet, and
A Miller
October 1976,
Journal of theoretical biology,
H G Coster, and
V J James, and
C Berthet, and
A Miller
March 1983,
Biochemistry,
H G Coster, and
V J James, and
C Berthet, and
A Miller
January 1969,
Journal of microscopy,
H G Coster, and
V J James, and
C Berthet, and
A Miller
August 1965,
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,
H G Coster, and
V J James, and
C Berthet, and
A Miller
January 1978,
Advances in biophysics,
H G Coster, and
V J James, and
C Berthet, and
A Miller
March 1973,
Biochimica et biophysica acta,
