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Clinicopathological, radiological, and histological studies were performed on urinary bladder neoplasia induced by N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in five adult beagle dogs and in ten adult mongrel dogs. Tumors of the urinary bladder developed in dogs given various daily doses of BBN p.o. for different periods. The latent period of tumor induction was 4 years in dogs receiving a daily dose of 80 mg of BBN, 2 to 2.5 years in dogs receiving a daily dose of 160 mg of BBN, and 1.5 years in dogs receiving a daily dose of 240 mg of BBN. The total dose of BBN ingested by the dogs until the first tumors were observed by urological examinations was nearly the same in all groups, 100 to 140 g. These results suggest that there is a correlation between dose and induction time, but further dose-response studies are required. Histologically, tumors of the urinary bladder were transitional cell papillomas or transitional cell carcinomas resembling morphologically those found in human cases. It is possible to observe the process of development of urinary bladder tumors from initial lesions to invasive tumors using routine urological examinations. We believe that this experimental model is valuable for clinicopathological studies of urinary bladder tumors.
E Okajima, and
T Hiramatsu, and
K Hirao, and
M Ijuin, and
Y Hirao, and
K Babaya, and
S Ikuma, and
S Ohara, and
T Shiomi, and
T Hijioka, and
H Ohishi
January 2024,
Methods in molecular biology (Clifton, N.J.),
E Okajima, and
T Hiramatsu, and
K Hirao, and
M Ijuin, and
Y Hirao, and
K Babaya, and
S Ikuma, and
S Ohara, and
T Shiomi, and
T Hijioka, and
H Ohishi
January 1993,
Anticancer research,
E Okajima, and
T Hiramatsu, and
K Hirao, and
M Ijuin, and
Y Hirao, and
K Babaya, and
S Ikuma, and
S Ohara, and
T Shiomi, and
T Hijioka, and
H Ohishi
August 1969,
Gan,
E Okajima, and
T Hiramatsu, and
K Hirao, and
M Ijuin, and
Y Hirao, and
K Babaya, and
S Ikuma, and
S Ohara, and
T Shiomi, and
T Hijioka, and
H Ohishi
January 1997,
Urological research,
E Okajima, and
T Hiramatsu, and
K Hirao, and
M Ijuin, and
Y Hirao, and
K Babaya, and
S Ikuma, and
S Ohara, and
T Shiomi, and
T Hijioka, and
H Ohishi
January 1990,
Virchows Archiv. B, Cell pathology including molecular pathology,
E Okajima, and
T Hiramatsu, and
K Hirao, and
M Ijuin, and
Y Hirao, and
K Babaya, and
S Ikuma, and
S Ohara, and
T Shiomi, and
T Hijioka, and
H Ohishi
August 1985,
Gan to kagaku ryoho. Cancer & chemotherapy,
E Okajima, and
T Hiramatsu, and
K Hirao, and
M Ijuin, and
Y Hirao, and
K Babaya, and
S Ikuma, and
S Ohara, and
T Shiomi, and
T Hijioka, and
H Ohishi
February 1999,
International journal of urology : official journal of the Japanese Urological Association,
E Okajima, and
T Hiramatsu, and
K Hirao, and
M Ijuin, and
Y Hirao, and
K Babaya, and
S Ikuma, and
S Ohara, and
T Shiomi, and
T Hijioka, and
H Ohishi
August 1987,
Journal of the National Cancer Institute,
E Okajima, and
T Hiramatsu, and
K Hirao, and
M Ijuin, and
Y Hirao, and
K Babaya, and
S Ikuma, and
S Ohara, and
T Shiomi, and
T Hijioka, and
H Ohishi
February 1977,
Gan,
E Okajima, and
T Hiramatsu, and
K Hirao, and
M Ijuin, and
Y Hirao, and
K Babaya, and
S Ikuma, and
S Ohara, and
T Shiomi, and
T Hijioka, and
H Ohishi
December 1999,
Carcinogenesis,
