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The hemodynamic effects of disopyramide phosphate, 2.0 mg/kg body weight, given intravenously over a period of five minutes were studied at rest and during exercise in ten patients without clinical or angiographic evidence of heart disease. Following disopyramide, the resting cardiac index was lower (4.0 +/- 0.6 vs 4.3 +/- 0.6 liters/min/m2, mean +/- 1 SD,P less than 0.05), while left ventricular end-diastolic pressure (16 +/- 4 vs 11 +/- 4 mm Hg, P less than 0.001), pulmonary arterial (PA) mean pressure (20 +/- 5 vs 17 +/- 5 mm Hg, P less than 0.05), and brachial arterial (BA) mean pressure (105 +/- 8 vs 96 +/- 7 mm Hg, P less than 0.05), were higher than the pre-infusion resting values. During exercise, there was no change in left ventricular end-diastolic pressure while cardiac index rose from 4.0 +/- 0.6 to 6.5 +/- 0.6 liters/min/m2 (P less than 0.001) and left ventricular stroke work index increased from 62 +/- 19 to 84 +/- 22 gm/beat/m2 (P less than 0.001). The normal hemodynamic response during exercise after disopyramide despite the apparent depression of left ventricular function at rest probably reflects the positive inotropic effect of enhanced sympathoadrenergic activity.
U Thadani, and
D Manyari, and
P Gregor, and
J Olowoyeye, and
A Leach, and
R O West, and
J O Parker
November 1958,
Journal of applied physiology,
U Thadani, and
D Manyari, and
P Gregor, and
J Olowoyeye, and
A Leach, and
R O West, and
J O Parker
February 1962,
American heart journal,
U Thadani, and
D Manyari, and
P Gregor, and
J Olowoyeye, and
A Leach, and
R O West, and
J O Parker
January 1972,
Circulation,
U Thadani, and
D Manyari, and
P Gregor, and
J Olowoyeye, and
A Leach, and
R O West, and
J O Parker
January 1979,
Bulletin europeen de physiopathologie respiratoire,
U Thadani, and
D Manyari, and
P Gregor, and
J Olowoyeye, and
A Leach, and
R O West, and
J O Parker
December 1971,
Chest,
U Thadani, and
D Manyari, and
P Gregor, and
J Olowoyeye, and
A Leach, and
R O West, and
J O Parker
January 1963,
Scandinavian journal of clinical and laboratory investigation,
U Thadani, and
D Manyari, and
P Gregor, and
J Olowoyeye, and
A Leach, and
R O West, and
J O Parker
January 1991,
Journal of cardiovascular pharmacology,
U Thadani, and
D Manyari, and
P Gregor, and
J Olowoyeye, and
A Leach, and
R O West, and
J O Parker
January 1974,
Acta cardiologica,
U Thadani, and
D Manyari, and
P Gregor, and
J Olowoyeye, and
A Leach, and
R O West, and
J O Parker
January 1967,
Scandinavian journal of respiratory diseases,
U Thadani, and
D Manyari, and
P Gregor, and
J Olowoyeye, and
A Leach, and
R O West, and
J O Parker
January 1984,
Acta medica Scandinavica. Supplementum,
