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We examined the ability of the mucus layer adherent to isolated pieces of rabbit gastric mucosa to maintain a pH gradient across it. Using antimony microelectrodes, a stable pH gradient was detected from pH 2.31 +/- 0.04 on the luminal side to pH 7.26 +/- 0.15 (n = 22) on the epithelial side of the mucus layer. The gradient was maintained for at least 60 minutes. A metabolic inhibitor, potassium cyanide, markedly reduced the tissues' ability to maintain this pH gradient, suggesting involvement of an active cellular process, probably that of bicarbonate secretion. These observations provide additional evidence in favour of a 'mucus-bicarbonate' barrier which may be of importance in protecting the underlying gastric mucosa.
S E Williams, and
L A Turnberg
June 1982,
Gut,
S E Williams, and
L A Turnberg
January 1982,
Advances in experimental medicine and biology,
S E Williams, and
L A Turnberg
January 1984,
Scandinavian journal of gastroenterology. Supplement,
S E Williams, and
L A Turnberg
October 1981,
Gastroenterology,
S E Williams, and
L A Turnberg
July 1984,
Sheng li ke xue jin zhan [Progress in physiology],
S E Williams, and
L A Turnberg
January 1989,
Scandinavian journal of gastroenterology. Supplement,
S E Williams, and
L A Turnberg
November 1984,
Gastroenterologie clinique et biologique,
S E Williams, and
L A Turnberg
April 1982,
Clinical science (London, England : 1979),
S E Williams, and
L A Turnberg
January 1989,
The American journal of physiology,
S E Williams, and
L A Turnberg
May 1997,
Gastroenterologia y hepatologia,
