Biomaterial Database

Thirst and sodium appetite after colloid treatment in rats. 1981

E M Stricker

Subcutaneous injection of polyethylene glycol (PEG) solution produced a progressive sequestration of extracellular fluid at the injection site. Appropriately, PEG-treated rats showed both thirst and sodium appetite. However, water intake began within 1 to 2 hr after the injections, whereas consumption of NaCl solution did not start until 3-4 hr later. Then rats ingested both fluids alternately until plasma volumes were restored, whereupon saline intake became even more prominent while water was consumed due to induced osmoregulatory needs. These three phases were seen regardless of the dose of PEG that was administered or the concentration of saline that was available. In contrast, after maintenance on a sodium-deficient diet for 2-4 days, or after bilateral adrenalectomy, rats increased their intake of saline immediately after PEG treatment. These and other findings suggest that the delayed onset of sodium appetite after PEG treatment that occurs when rats are maintained on standard sodium-rich chow results from the buffer provided by surplus extracellular fluid in those animals. They further suggest that sodium appetite is not directly associated with decreases in plasma volume or sodium concentration but instead may be stimulated by decreased availability of sodium in the brain.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D011092	Polyethylene Glycols	Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS.	Macrogols,Polyoxyethylenes,Carbowax,Macrogol,Polyethylene Glycol,Polyethylene Oxide,Polyethyleneoxide,Polyglycol,Glycol, Polyethylene,Glycols, Polyethylene,Oxide, Polyethylene,Oxides, Polyethylene,Polyethylene Oxides,Polyethyleneoxides,Polyglycols,Polyoxyethylene
D001810	Blood Volume	Volume of circulating BLOOD. It is the sum of the PLASMA VOLUME and ERYTHROCYTE VOLUME.	Blood Volumes,Volume, Blood,Volumes, Blood
D004326	Drinking	The consumption of liquids.	Water Consumption,Water Intake,Drinkings
D005110	Extracellular Space	Interstitial space between cells, occupied by INTERSTITIAL FLUID as well as amorphous and fibrous substances. For organisms with a CELL WALL, the extracellular space includes everything outside of the CELL MEMBRANE including the PERIPLASM and the cell wall.	Intercellular Space,Extracellular Spaces,Intercellular Spaces,Space, Extracellular,Space, Intercellular,Spaces, Extracellular,Spaces, Intercellular
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001066	Appetite	Natural recurring desire for food. Alterations may be induced by APPETITE DEPRESSANTS or APPETITE STIMULANTS.	Appetite Alterations,Alteration, Appetite,Alterations, Appetite,Appetite Alteration,Appetites
D012964	Sodium	A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.	Sodium Ion Level,Sodium-23,Ion Level, Sodium,Level, Sodium Ion,Sodium 23
D013894	Thirst	A drive stemming from a physiological need for WATER.	Thirsts
D014882	Water-Electrolyte Balance	The balance of fluid in the BODY FLUID COMPARTMENTS; total BODY WATER; BLOOD VOLUME; EXTRACELLULAR SPACE; INTRACELLULAR SPACE, maintained by processes in the body that regulate the intake and excretion of WATER and ELECTROLYTES, particularly SODIUM and POTASSIUM.	Fluid Balance,Electrolyte Balance,Balance, Electrolyte,Balance, Fluid,Balance, Water-Electrolyte,Water Electrolyte Balance