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This double-blind randomized study compared the effects of imipramine (48 patients) and doxepin (49 patients) in psychoneurotic depressed patients with sleep disturbance symptoms. Mean doses of 112.7 mg/day for doxepin and 116.7 mg/day for imipramine were administered for a mean period of 26 days. While both drugs proved effective, 24 of 27 analyses of covariance showed imipramine to be superior to doxepin. This superiority was statistically significant for the anxiety/depression factor measured on the Hamilton Depression Scale and for the total score, general neurotic feelings factor, cognitive performance difficulty factor and anger-hostility cluster on the Lepman-Rickels Scale. Mild-to-moderate side effects were prevalent to a comparable degree in both treatment groups.
R J Finnerty, and
H L Goldberg, and
K Rickels
January 1993,
International clinical psychopharmacology,
R J Finnerty, and
H L Goldberg, and
K Rickels
December 1973,
Current therapeutic research, clinical and experimental,
R J Finnerty, and
H L Goldberg, and
K Rickels
June 1996,
International clinical psychopharmacology,
R J Finnerty, and
H L Goldberg, and
K Rickels
December 1989,
Sleep,
R J Finnerty, and
H L Goldberg, and
K Rickels
November 1989,
Wiener medizinische Wochenschrift (1946),
R J Finnerty, and
H L Goldberg, and
K Rickels
June 1971,
Current therapeutic research, clinical and experimental,
R J Finnerty, and
H L Goldberg, and
K Rickels
January 1972,
Psychosomatics,
R J Finnerty, and
H L Goldberg, and
K Rickels
November 1982,
The Journal of clinical psychiatry,
R J Finnerty, and
H L Goldberg, and
K Rickels
October 2004,
Psychopharmacology,
R J Finnerty, and
H L Goldberg, and
K Rickels
October 1982,
The Journal of clinical psychiatry,
