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Allophenic mice in cleft-palate investigations. 1978

K M Sulik, and R L Atnip

T1Wh (Rb (5;19)1Wh), an albino strain of mice not previously used in the investigation of cleft palate (CP), is homozygous for a (5;19) Robertsonian translocation which provides conspicuous chromosomal markers. Preliminary studies in this laboratory revealed that CP is induced in all the offspring of T1Wh females treated with 2.5 mg of cortisone acetate on days 11-14 of pregnancy and that palatal closure is accomplished at a later morphological and chronological age than in C57BL/6J strain mice. The latter strain had a CP frequency of 42% under similar experimental conditions. Eight- to 16-cell embryos were aggregated in the following combinations: T1Wh in equilibrium T1Wh, C57BL/6J in equilibrium C57BL/6J and T1Wh in equilibrium C57BL/6J. The resulting allophenic blastocysts were transferred to pseudopregnant C57BL/6J recipients which were given the above cortisone treatment and killed on the 18th day of pregnancy. CP was found in all of the 48 T1Wh in equilibrium T1Wh fetuses, 4 (20%) of of 20 C57BL/6J in equilibrium C57BL/6J fetuses and in 17 (26.2%) of 65 T1Wh in equilibrium C57BL/6J fetuses. Analysis of chromosome preparations from the palates of the T1Wh in equilibrium C57BL/6J fetuses demonstrated that there is a positive correlation between the presence of CP and the percentage of susceptible cells in the palate (P less than 0.02). Other data suggest a possible growth advantage in favor of C57BL/6J cells in the palates of T1Wh in equilibrium C57BL/6J allophenic mice.

UI MeSH Term Description Entries
D008815 Mice, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation. Inbred Mouse Strains,Inbred Strain of Mice,Inbred Strain of Mouse,Inbred Strains of Mice,Mouse, Inbred Strain,Inbred Mouse Strain,Mouse Inbred Strain,Mouse Inbred Strains,Mouse Strain, Inbred,Mouse Strains, Inbred,Strain, Inbred Mouse,Strains, Inbred Mouse
D009030 Mosaicism The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from a single ZYGOTE, as opposed to CHIMERISM in which the different cell populations are derived from more than one zygote.
D010159 Palate The structure that forms the roof of the mouth. It consists of the anterior hard palate (PALATE, HARD) and the posterior soft palate (PALATE, SOFT). Incisive Papilla,Incisive Papillas,Palates,Papilla, Incisive,Papillas, Incisive
D002875 Chromosomes In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) Chromosome
D002972 Cleft Palate Congenital fissure of the soft and/or hard palate, due to faulty fusion. Cleft Palate, Isolated,Cleft Palates,Palate, Cleft,Palates, Cleft
D003348 Cortisone A naturally occurring glucocorticoid that has been used in replacement therapy for ADRENAL INSUFFICIENCY and as an anti-inflammatory agent. Cortisone itself is inactive; it is converted in the liver to the active metabolite HYDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726) 17-Hydroxy-3,11,20-trioxopregn-4-en-21-yl acetate,Adreson,Cortisone Acetate,Cortone Acetate
D005127 Eye Color Color of the iris. Color, Eye,Colors, Eye,Eye Colors
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus

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