Biomaterial Database

Cardiopulmonary effects of butorphanol tartrate in horses. 1981

J T Robertson, and W W Muir, and R Sams

The cardiopulmonary and behavioral effects of butorphanol were evaluated in pain-free adult horses. Butorphanol tartrate was administered IV in doses of 0.1, 0.2, and 0.4 mg/kg to the same horses on 3 separate occasions. There were no significant (P less than 0.05) changes in heart rate, mean and diastolic arterial pressure, mean and diastolic pulmonary arterial blood pressure, or cardiac output recorded in the horses given these doses. Systolic arterial blood pressure was significantly (P less than 0.05) increased in only the horses given the 0.2 mg/kg dose. Significant (P greater than 0.05) changes in electrocardiographic intervals, respiratory rate, arterial blood gas values, or pH were not recorded. Increasing IV doses of butorphanol resulted in varied behavioral changes, but were predominantly excitatory.

UI	MeSH Term	Description	Entries
D009019	Morphinans	Compounds based on a partially saturated iminoethanophenanthrene, which can be described as ethylimino-bridged benzo-decahydronaphthalenes. They include some of the OPIOIDS found in PAPAVER that are used as ANALGESICS.	Morphinan
D012119	Respiration	The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (	Breathing
D001794	Blood Pressure	PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.	Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D002077	Butorphanol	A synthetic morphinan analgesic with narcotic antagonist action. It is used in the management of severe pain.	17-(Cyclobutylmethyl)morphinan-3,14-diol,Apo-Butorphanol,BC-2627,Beforal,Butorphanol Tartrate,Dolorex,Moradol,Stadol,Stadol NS,Torbugesic,BC 2627,BC2627
D002319	Cardiovascular System	The HEART and the BLOOD VESSELS by which BLOOD is pumped and circulated through the body.	Circulatory System,Cardiovascular Systems,Circulatory Systems
D006736	Horses	Large, hoofed mammals of the family EQUIDAE. Horses are active day and night with most of the day spent seeking and consuming food. Feeding peaks occur in the early morning and late afternoon, and there are several daily periods of rest.	Equus caballus,Equus przewalskii,Horse, Domestic,Domestic Horse,Domestic Horses,Horse,Horses, Domestic
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001011	Aorta	The main trunk of the systemic arteries.	Aortas
D001522	Behavior, Animal	The observable response an animal makes to any situation.	Autotomy Animal,Animal Behavior,Animal Behaviors