BIOMAT Database Logo BIOMAT Database Logo

Comparison of transbronchial and open biopsies in chronic infiltrative lung diseases. 1981

C P Wall, and E A Gaensler, and C B Carrington, and J A Hayes

To ascertain the diagnostic reliability of transbronchial biopsy (TBB) a prospective comparison with open lung biopsy was made. All patients with undiagnosed diffuse infiltrative (interstitial) lung disease had a TBB. When this was characteristic of tumor, sarcoidosis, or infection, no additional biopsy was deemed necessary. In all other patients, an open biopsy was performed. Between January 1976 and May 1980, among 176 patients with interstitial disease, 60 (34.1%) required lung biopsy. Transbronchial biopsy was contraindicated in 7, leaving 53 in the study group. Among these 53 patients TBB was diagnostic in 20 (37.7%), and the histologic findings in the remaining 33 patients who lacked definitive tissue diagnoses were reported as normal lung, 10 patients; nonspecific abnormalities, 11 patients; interstitial pneumonia, 6; interstitial fibrosis, 3; inadequate specimen, 3. Open biopsy in these 33 patients resulted in specific diagnoses in 92%, and these diagnoses bore little relationship to the original TBB diagnoses. We concluded that TBB diagnoses of interstitial pneumonia, chronic inflammation, nonspecific reaction, and fibrosis are unreliable and often entirely misleading. In this group, an open biopsy is required to reach a specific histologic diagnosis.

UI MeSH Term Description Entries
D008168 Lung Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood. Lungs
D008175 Lung Neoplasms Tumors or cancer of the LUNG. Cancer of Lung,Lung Cancer,Pulmonary Cancer,Pulmonary Neoplasms,Cancer of the Lung,Neoplasms, Lung,Neoplasms, Pulmonary,Cancer, Lung,Cancer, Pulmonary,Cancers, Lung,Cancers, Pulmonary,Lung Cancers,Lung Neoplasm,Neoplasm, Lung,Neoplasm, Pulmonary,Pulmonary Cancers,Pulmonary Neoplasm
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011658 Pulmonary Fibrosis A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death. Alveolitis, Fibrosing,Idiopathic Diffuse Interstitial Pulmonary Fibrosis,Fibroses, Pulmonary,Fibrosis, Pulmonary,Pulmonary Fibroses,Alveolitides, Fibrosing,Fibrosing Alveolitides,Fibrosing Alveolitis
D002908 Chronic Disease Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2). Chronic Condition,Chronic Illness,Chronically Ill,Chronic Conditions,Chronic Diseases,Chronic Illnesses,Condition, Chronic,Disease, Chronic,Illness, Chronic
D003937 Diagnosis, Differential Determination of which one of two or more diseases or conditions a patient is suffering from by systematically comparing and contrasting results of diagnostic measures. Diagnoses, Differential,Differential Diagnoses,Differential Diagnosis
D005260 Female Females
D006105 Granulomatous Disease, Chronic A defect of leukocyte function in which phagocytic cells ingest but fail to digest bacteria, resulting in recurring bacterial infections with granuloma formation. When chronic granulomatous disease is caused by mutations in the CYBB gene, the condition is inherited in an X-linked recessive pattern. When chronic granulomatous disease is caused by CYBA, NCF1, NCF2, or NCF4 gene mutations, the condition is inherited in an autosomal recessive pattern. Autosomal Recessive Chronic Granulomatous Disease,Chronic Granulomatous Disease,Chronic Granulomatous Disease, Atypical,Chronic Granulomatous Disease, X-Linked,Cytochrome B-Negative Granulomatous Disease, Chronic, X-Linked,Cytochrome B-Positive Granulomatous Disease, Chronic, X-Linked,Granulomatous Disease, Chronic, X-Linked,Granulomatous Disease, Chronic, X-Linked, Variant,X-Linked Chronic Granulomatous Disease,Chronic Granulomatous Disease, X Linked,Chronic Granulomatous Diseases,Granulomatous Diseases, Chronic,X Linked Chronic Granulomatous Disease
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

C P Wall, and E A Gaensler, and C B Carrington, and J A Hayes
[Transbronchial and open lung biopsies in diffuse infiltrative lung diseases. A review].
March 1990, Nihon rinsho. Japanese journal of clinical medicine,
C P Wall, and E A Gaensler, and C B Carrington, and J A Hayes
Comparison of transbronchial and open lung biopsies in interstitial lung diseases.
January 1988, Archivos de investigacion medica,
C P Wall, and E A Gaensler, and C B Carrington, and J A Hayes
[Transbronchial biopsy in diffuse infiltrative lung diseases].
May 1999, Orvosi hetilap,
C P Wall, and E A Gaensler, and C B Carrington, and J A Hayes
Role of transbronchial biopsies in pediatric lung diseases.
July 2004, Chest,
C P Wall, and E A Gaensler, and C B Carrington, and J A Hayes
Transbronchial lung biopsy and bronchoalveolar lavage in diagnosis of diffuse infiltrative lung diseases.
January 1988, Respiration; international review of thoracic diseases,
C P Wall, and E A Gaensler, and C B Carrington, and J A Hayes
Utility of Core Needle Biopsies and Transbronchial Biopsies for Diagnosing Nonneoplastic Lung Diseases.
September 2018, Archives of pathology & laboratory medicine,
C P Wall, and E A Gaensler, and C B Carrington, and J A Hayes
Complications of transbronchial lung biopsies.
May 1978, Chest,
C P Wall, and E A Gaensler, and C B Carrington, and J A Hayes
Which biopsies in diffuse infiltrative lung diseases and when are these necessary?
October 2001, Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace,
C P Wall, and E A Gaensler, and C B Carrington, and J A Hayes
Transcripts associated with chronic lung allograft dysfunction in transbronchial biopsies of lung transplants.
April 2022, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons,
C P Wall, and E A Gaensler, and C B Carrington, and J A Hayes
[Infiltrative lung diseases].
January 2010, Presse medicale (Paris, France : 1983),
Copied contents to your clipboard!