[Digestive utilization of cis and trans docosenoic acids in the rat: effects of dietary levels of calcium and linoleic acid]. 1980

P O Astorg

Digestibilities of cis and trans docosenoic acids (C 22:11) have been determined in male growing Wistar rats. Eight groups of rats were fed diets with 0.04 or 0.92% calcium and 15% lipids; the latter contained about 46% cis or trans C:22:1, and 1.5 or 28% linoleic acid. Food consumption was recorded and faeces were collected during 9 days. Fecal lipids were extracted in two fractions: soluble (in chloroform), and insoluble; the fatty acids of both fractions were analysed by gas-liquid chromatography. Calcium and, in some cases, Phosphorus, were determined in the soluble fraction. The digestibility of brassidic acid was strongly lowered by the presence of Calcium in the diet (-35 points). This was due to the massive formation, in the gut, of insoluble Calcium complexes (probably Calcium soaps) of brassidic acid. Dietary linoleic acid improves the absorption of brassidic acid (+ 17 points). This effect could result from the lower melting point of the dietary fat (37 degrees C instead of 48 degrees C) and/or from the emulsifying properties of monolinolein in the intestine. The effects of Calcium and of linoleic acid were additives. In the most favourable conditions (no Calcium, 28% linoleic acid), brassidic acid digestibility reached 98%. Erucic acid digestibility was decreased by dietary Calcium, but to a lesser extent than that of brassidic acid (-17 points). Here again, the formation in the gut of Calcium erucate and Calcium-Phosphorus-erucate complexes was responsible of this phenomenon. As a matter of fact, the digestibility of erucic acid reached nearly 100% when no Calcium was added to the diet. The absorption of erucic acid was not improved by dietary linoleic acid.

UI MeSH Term Description Entries
D007536 Isomerism The phenomenon whereby certain chemical compounds have structures that are different although the compounds possess the same elemental composition. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed) Isomerisms
D008041 Linoleic Acids Eighteen-carbon essential fatty acids that contain two double bonds. Acids, Linoleic
D008297 Male Males
D010758 Phosphorus A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions. Black Phosphorus,Phosphorus-31,Red Phosphorus,White Phosphorus,Yellow Phosphorus,Phosphorus 31,Phosphorus, Black,Phosphorus, Red,Phosphorus, White,Phosphorus, Yellow
D002118 Calcium A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. Coagulation Factor IV,Factor IV,Blood Coagulation Factor IV,Calcium-40,Calcium 40,Factor IV, Coagulation
D002136 Calcium, Dietary Calcium compounds in DIETARY SUPPLEMENTS or in food that supply the body with calcium. Dietary Calcium
D004041 Dietary Fats Fats present in food, especially in animal products such as meat, meat products, butter, ghee. They are present in lower amounts in nuts, seeds, and avocados. Fats, Dietary,Dietary Fat,Fat, Dietary
D004063 Digestion The process of breakdown of food for metabolism and use by the body.
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004883 Erucic Acids cis-13-Docosenoic Acids. 22-Carbon monounsaturated, monocarboxylic acids. Docosenoic Acids,Brassidic Acids,Acids, Brassidic,Acids, Docosenoic,Acids, Erucic

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