Biomaterial Database

The influence of organic chelators on the toxicity of copper to embryos of the Pacific oyster, Crassostrea gigas. 1981

J P Knezovich, and F L Harrison, and J S Tucker

The effects of copper on the development of Crassostrea gigas embryos were determined with a 48-hr static bioassay. In filtered, sterilized seawater from Bodega Bay, California, the LC100 was 20 microgram Cu/L, and the LC50 was 12 microgram Cu/L. Destruction of the naturally occurring dissolved organic material in the culture water by UV oxidation decreased embryo survival at 10 microgram Cu/L. The addition to seawater of five organic chelators (ethylenediaminetetraacetic acid (EDTA), sodium citrate, glycine, and oxalate at 1 x 10(-6) M, and humic matter at 2 mg/L) increased embryo survival. EDTA and humic matter were the most effective chelators; EDTA significantly increased survival at 100 microgram Cu/L and humic matter did so at 40 microgram Cu/L. The ability of a chelator to increase survival was related to the stability constant of the copper-chelator complex.

UI	MeSH Term	Description	Entries
D007928	Lethal Dose 50	The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population.	LD50,Dose 50, Lethal
D010125	Ostreidae	A family of marine mollusks in the class BIVALVIA, commonly known as oysters. They have a rough irregular shell closed by a single adductor muscle.	Oysters,Oyster
D002614	Chelating Agents	Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS.	Chelating Agent,Chelator,Complexons,Metal Antagonists,Chelators,Metal Chelating Agents,Agent, Chelating,Agents, Chelating,Agents, Metal Chelating,Antagonists, Metal,Chelating Agents, Metal
D003300	Copper	A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.	Copper-63,Copper 63
D004347	Drug Interactions	The action of a drug that may affect the activity, metabolism, or toxicity of another drug.	Drug Interaction,Interaction, Drug,Interactions, Drug
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014867	Water	A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)	Hydrogen Oxide
D014873	Water Pollutants	Substances or organisms which pollute the water or bodies of water. Use for water pollutants in general or those for which there is no specific heading.	Water Pollutant,Pollutant, Water,Pollutants, Water
D014874	Water Pollutants, Chemical	Chemical compounds which pollute the water of rivers, streams, lakes, the sea, reservoirs, or other bodies of water.	Chemical Water Pollutants,Landfill Leachate,Leachate, Landfill,Pollutants, Chemical Water