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A sensitive, specific, high-pressure liquid chromatographic assay for the determination of tocainide in whole blood is described. The residue from a methylene chloride extract of alkalinized blood was resolvated in a mobile phase of methanol--water (47:53) containing 1% acetic acid and 6.16 mM 1-octanesulfonic acid, adjusted to pH 4.0. Chromatography was performed on a reversed-phase column with detection at 254 or 225 nm. The limits of accurate measurement were 2 microgram/ml for a 1-ml blood sample monitored at 254 nm and 0.2 microgram/ml for a 2-ml sample monitored at 225 nm. The assay was tested on samples from emergency protocol patients and was also found suitable for single-dose pharmacokinetic studies.
E M Wolshin, and
M H Cavanaugh, and
C V Manion, and
M B Meyer, and
E Milano, and
C R Reardon, and
S M Wolshin
March 1981,
Journal of pharmaceutical sciences,
E M Wolshin, and
M H Cavanaugh, and
C V Manion, and
M B Meyer, and
E Milano, and
C R Reardon, and
S M Wolshin
January 1981,
Chemotherapy,
E M Wolshin, and
M H Cavanaugh, and
C V Manion, and
M B Meyer, and
E Milano, and
C R Reardon, and
S M Wolshin
April 1977,
Antimicrobial agents and chemotherapy,
E M Wolshin, and
M H Cavanaugh, and
C V Manion, and
M B Meyer, and
E Milano, and
C R Reardon, and
S M Wolshin
July 1978,
Journal of chromatography,
E M Wolshin, and
M H Cavanaugh, and
C V Manion, and
M B Meyer, and
E Milano, and
C R Reardon, and
S M Wolshin
July 1989,
Journal of forensic sciences,
E M Wolshin, and
M H Cavanaugh, and
C V Manion, and
M B Meyer, and
E Milano, and
C R Reardon, and
S M Wolshin
August 1975,
Journal of pharmaceutical sciences,
E M Wolshin, and
M H Cavanaugh, and
C V Manion, and
M B Meyer, and
E Milano, and
C R Reardon, and
S M Wolshin
December 1977,
Analytical biochemistry,
E M Wolshin, and
M H Cavanaugh, and
C V Manion, and
M B Meyer, and
E Milano, and
C R Reardon, and
S M Wolshin
June 1980,
Analytical biochemistry,
E M Wolshin, and
M H Cavanaugh, and
C V Manion, and
M B Meyer, and
E Milano, and
C R Reardon, and
S M Wolshin
June 1975,
Journal of pharmaceutical sciences,
E M Wolshin, and
M H Cavanaugh, and
C V Manion, and
M B Meyer, and
E Milano, and
C R Reardon, and
S M Wolshin
July 1978,
Journal of pharmaceutical sciences,
